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June 2019 - July 1959




May 2019, Vol 76, No. 5, Pages 513-626

In This Issue of JAMA Neurology


Abstract Full Text
free access
JAMA Neurol. 2019;76(5):513. doi:10.1001/jamaneurol.2018.2986

Concussion Biomarkers: Deviating From the Garden Path

Abstract Full Text
JAMA Neurol. 2019;76(5):515-516. doi:10.1001/jamaneurol.2019.0125

This Viewpoint discusses the strengths and weaknesses of using biomarkers to diagnose concussion.

Untethering Idea Generation From Protocol Execution in Neurorehabilitation Research

Abstract Full Text
JAMA Neurol. 2019;76(5):517-518. doi:10.1001/jamaneurol.2018.4918

This Viewpoint discusses the benefits of a system of collaboration between idea generators and experimentalists at high-volume protocol execution hubs.

On the Brain

If You See Something, Say Something

Abstract Full Text
JAMA Neurol. 2019;76(5):519-520. doi:10.1001/jamaneurol.2019.0597

In this article, the authors mull the emotional difficulties and ethical obligations associated with noticing symptoms of possible medical problems on strangers and other nonpatients.


Potential New Horizons for the Prevention of Cerebrovascular Diseases and Dementia

Abstract Full Text
JAMA Neurol. 2019;76(5):521-522. doi:10.1001/jamaneurol.2018.4406

One Step Closer to Precision Medicine Strategies Based on Genetic Information: ABCB1 Polymorphisms in the CHANCE Trial

Abstract Full Text
JAMA Neurol. 2019;76(5):523-525. doi:10.1001/jamaneurol.2018.4404
Original Investigation

Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(5):526-535. doi:10.1001/jamaneurol.2019.0079

This post hoc analysis of Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial assesses the association of pioglitazone vs placebo with recurrent stroke, myocardial infarction, and other cardiovascular events.

Clinical Outcomes of Escalation vs Early Intensive Disease-Modifying Therapy in Patients With Multiple Sclerosis

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(5):536-541. doi:10.1001/jamaneurol.2018.4905

This cohort study analyzes long-term outcomes in a patients with multiple sclerosis according to initial treatment strategy.

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults

Abstract Full Text
JAMA Neurol. 2019;76(5):542-551. doi:10.1001/jamaneurol.2018.4693

This analysis of 2 cross-sectional cohort studies examines the sex differences in the association between β-amyloid and regional tau deposition as measured with positron emission tomography (PET).

Association Between ABCB1 Polymorphisms and Outcomes of Clopidogrel Treatment in Patients With Minor Stroke or Transient Ischemic Attack: Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(5):552-560. doi:10.1001/jamaneurol.2018.4775

This secondary analysis of the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) randomized clinical trial investigates the association of ABCB1 polymorphisms with efficacy of clopidogrel plus aspirin vs aspirin alone in patients with minor stroke or transient ischemic attack.

Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2019;76(5):561-570. doi:10.1001/jamaneurol.2018.4858

This validation study describes the development of a prognostic model to predict swallowing recovery and guide the decision for enteral tube feeding in people with dysphagia after ischemic stroke.

Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(5):571-579. doi:10.1001/jamaneurol.2018.4822

This randomized clinical trial assesses whether moderate hypothermia after early hemicraniectomy reduces mortality in patients with malignant MCA stroke, compared with standard treatment.

Assessing Spinal Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension With a Scoring System Based on Brain Magnetic Resonance Imaging Findings

Abstract Full Text
JAMA Neurol. 2019;76(5):580-587. doi:10.1001/jamaneurol.2018.4921

This case-control study assesses brain magnetic resonance imaging data to develop a probability score of cerebrospinal fluid leak in patients with spontaneous intracranial hypotension.

Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2019;76(5):588-597. doi:10.1001/jamaneurol.2019.0006

This systematic review and meta-analysis assesses worldwide aneurysmal subarachnoid hemorrhage incidence according to region, age, sex, time period, blood pressure, and smoking prevalence.

Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes

Abstract Full Text
JAMA Neurol. 2019;76(5):598-606. doi:10.1001/jamaneurol.2018.4666

This cohort study assesses the association between plasma total tau level and later development of dementia by comparing laboratory, clinical, and autopsy data from participants in the Framingham Heart Study in the United States and the Memento Study in France.

Brief Report

Findings of Impaired Hearing in Patients With Nonfluent/Agrammatic Variant Primary Progressive Aphasia

Abstract Full Text
open access
JAMA Neurol. 2019;76(5):607-611. doi:10.1001/jamaneurol.2018.4799

This cross-sectional study compares peripheral hearing function in individuals with nonfluent/agrammatic variant primary progressive aphasia with that of patients with Alzheimer disease and healthy control participants.


Neurocritical Care Outcomes, Research, and Technology: A Review

Abstract Full Text
JAMA Neurol. 2019;76(5):612-618. doi:10.1001/jamaneurol.2018.4407

This narrative review discusses the components of neurocritical care and the contributions of the subspecialty to patient quality of care and the health care system.

Images in Neurology

Acute Disseminated Encephalomyelitis After Chikungunya Infection

Abstract Full Text
JAMA Neurol. 2019;76(5):619. doi:10.1001/jamaneurol.2019.0113

A 16-year-old girl presented with progressive diffuse pain in the lower limbs associated with paresis and unstable gait following Chikungunya infection.

The Deep Brain Stimulation “Twiddler Syndrome”

Abstract Full Text
JAMA Neurol. 2019;76(5):620. doi:10.1001/jamaneurol.2019.0691

This case report describes a woman in her late 60s who presented with right-hand rest tremor, micrographia, declining mobility, slowness of gait, and freezing episodes.

JAMA Neurology Clinical Challenge

Strokelike Episodes in a Patient With Chronic Gait Abnormalities

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(5):621-622. doi:10.1001/jamaneurol.2019.0057

A 13-year-old boy with a longstanding history of gait imbalance presented with 2 episodes of acute-onset left hemibody weakness and dysarthria without changes in sensorium in a 24-hour period. What is your diagnosis?

Comment & Response

Time Is Brain and Spine

Abstract Full Text
JAMA Neurol. 2019;76(5):623. doi:10.1001/jamaneurol.2019.0146

Time Is Brain and Spine—Reply

Abstract Full Text
JAMA Neurol. 2019;76(5):623-624. doi:10.1001/jamaneurol.2019.0149

Variations in Modeling for Treating All Patients With Stroke With Suspected Large Vessel Occlusion

Abstract Full Text
JAMA Neurol. 2019;76(5):624. doi:10.1001/jamaneurol.2019.0348

Variations in Modeling for Treating Acute Stroke—Reply

Abstract Full Text
JAMA Neurol. 2019;76(5):624-625. doi:10.1001/jamaneurol.2019.0367

Error in Discussion Section

Abstract Full Text
free access
JAMA Neurol. 2019;76(5):625-626. doi:10.1001/jamaneurol.2019.0475

Errors in Multiple Sections

Abstract Full Text
free access
JAMA Neurol. 2019;76(5):626. doi:10.1001/jamaneurol.2019.0131
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2019;76(5):514. doi:10.1001/jamaneurol.2018.2987