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August 2019 - July 1959




June 2019, Vol 76, No. 6, Pages 629-732

In This Issue of JAMA Neurology


Abstract Full Text
free access
JAMA Neurol. 2019;76(6):629. doi:10.1001/jamaneurol.2018.2991

Preclinical Alzheimer Disease and the Dawn of the Pre-Caregiver

Abstract Full Text
JAMA Neurol. 2019;76(6):631-632. doi:10.1001/jamaneurol.2019.0165

This Viewpoint discusses the emerging role of the pre-caregiver in preclinical Alzheimer disease.

Health and Socioeconomic Inequities as Contributors to Brain Health

Abstract Full Text
JAMA Neurol. 2019;76(6):633-634. doi:10.1001/jamaneurol.2019.0362

This Viewpoint describes the increasing global prevalence of dementia and the steps necessary to help address attendant health care needs worldwide.

On the Brain

Confronting My Bias

Abstract Full Text
JAMA Neurol. 2019;76(6):635-636. doi:10.1001/jamaneurol.2019.0841

This essay describes a physician’s self-reflection and analysis about her own gender bias.


Thrombolysis Works in Lacunar Infarct, Complicating Imaging Selection

Abstract Full Text
JAMA Neurol. 2019;76(6):637-638. doi:10.1001/jamaneurol.2019.0214

Common Premutations in the General Population

Abstract Full Text
JAMA Neurol. 2019;76(6):639-640. doi:10.1001/jamaneurol.2019.0216
Original Investigation

Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial

Abstract Full Text
JAMA Neurol. 2019;76(6):641-649. doi:10.1001/jamaneurol.2019.0351

This secondary post hoc analysis of data from the WAKE-UP randomized clinial trial compares patients with lacunar and nonlacunar strokes to assess whether intravenous thrombolysis with altaplase is useful in these patients.

Prevalence of Carriers of Intermediate and Pathological Polyglutamine Disease–Associated Alleles Among Large Population-Based Cohorts

Abstract Full Text
JAMA Neurol. 2019;76(6):650-656. doi:10.1001/jamaneurol.2019.0423

This cross-sectional study of 5 European cohort studies determines the prevalence of carriers of intermediate and pathological polyglutamine disease–associated alleles among the general population.

Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results

Abstract Full Text
JAMA Neurol. 2019;76(6):657-664. doi:10.1001/jamaneurol.2019.0072

This randomized clinical trial examines whether antiplatelent or anticoagulant therapy is more effective in preventing stroke in cervical dissection and the risk of recurrent stroke in a randomized clinical trial setting.

Changes in the Risk of Reaching Multiple Sclerosis Disability Milestones In Recent Decades: A Nationwide Population-Based Cohort Study in Sweden

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(6):665-671. doi:10.1001/jamaneurol.2019.0330

This cohort study investigates whether the risk of reaching disability milestones of multiple sclerosis has changed over the last decade in Sweden.

Analysis of Morbidity and Outcomes Associated With Use of Subdural Grids vs Stereoelectroencephalography in Patients With Intractable Epilepsy

Abstract Full Text
has audio
JAMA Neurol. 2019;76(6):672-681. doi:10.1001/jamaneurol.2019.0098

This comparative analysis assesses the efficacy, procedural morbidity, and epilepsy outcomes of 2 patient populations undergoing stereoelectroencephalography vs subdural electrode implantation for evaluation of intractable epilepsy.

Outcomes of Thrombectomy in Transferred Patients With Ischemic Stroke in the Late Window: A Subanalysis From the DEFUSE 3 Trial

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(6):682-689. doi:10.1001/jamaneurol.2019.0118

This secondary analysis of the Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 trial evaluates whether the imaging-based selection criteria used in the trial would lead to comparable outcome rates and treatment benefits in transfer vs direct-admission patients with ischemic stroke.

Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy

Abstract Full Text
JAMA Neurol. 2019;76(6):690-700. doi:10.1001/jamaneurol.2019.0204

This multicenter cohort study assesses outcomes of piriform cortex resection among patients with temporal lobe epilepsy.

Fractures and Linear Growth in a Nationwide Cohort of Boys With Duchenne Muscular Dystrophy With and Without Glucocorticoid Treatment: Results From the UK NorthStar Database

Abstract Full Text
JAMA Neurol. 2019;76(6):701-709. doi:10.1001/jamaneurol.2019.0242

This study analyzes the fracture burden and growth impairment in a large contemporary cohort of boys with Duchenne muscular dystrophy in the United Kingdom and in relation to glucocorticoid regimen.

Association of MAPT Subhaplotypes With Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology

Abstract Full Text
JAMA Neurol. 2019;76(6):710-717. doi:10.1001/jamaneurol.2019.0250

This case-control study investigates the associations of MAPT haplotypes with the risk of progressive supranuclear palsy and the severity of tau pathology using a large series of neuropathologically confirmed progressive supranuclear palsy cases.


Compensation Strategies for Gait Impairments in Parkinson Disease: A Review

Abstract Full Text
has multimedia
JAMA Neurol. 2019;76(6):718-725. doi:10.1001/jamaneurol.2019.0033

This narrative review describes a range of techniques invented by patients with Parkinson disease to mitigate gait disorders, including freezing of gait.

Images in Neurology

Spinal Claudication Secondary to Anterior Disco-Osteo-Arterial Conflict and Mimicking Stiff Person Syndrome

Abstract Full Text
JAMA Neurol. 2019;76(6):726-727. doi:10.1001/jamaneurol.2019.1007

This article describes the case of a 68-year-old man with severe muscle spasms in his lower back and pelvis and unusual angiographic imaging results that led to an uncommon diagnosis.

JAMA Neurology Clinical Challenge

Recurrent Involuntary Contractions of the Face, Arm, and Leg in an Elderly Man

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2019;76(6):728-731. doi:10.1001/jamaneurol.2019.0452

A man in his 60s presents to an epilepsy monitoring unit with transient episodes of expressive speech difficulties, paroxysmal dizziness, and involuntary nonsuppressible jerks of the right arm that begin without warning. What is your diagnosis?

Comment & Response

Proper or Improper Use of the Crossover Design in Clinical Trials in Chronic Sciatica?

Abstract Full Text
JAMA Neurol. 2019;76(6):731. doi:10.1001/jamaneurol.2019.0870

Proper or Improper Use of the Crossover Design in Clinical Trials in Chronic Sciatica?—Reply

Abstract Full Text
JAMA Neurol. 2019;76(6):731-732. doi:10.1001/jamaneurol.2019.0873

Incorrectly Categorized Group Author

Abstract Full Text
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JAMA Neurol. 2019;76(6):732. doi:10.1001/jamaneurol.2019.0904

Error in Reference Citation

Abstract Full Text
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JAMA Neurol. 2019;76(6):732. doi:10.1001/jamaneurol.2019.1049

Error in Abstract

Abstract Full Text
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JAMA Neurol. 2019;76(6):732. doi:10.1001/jamaneurol.2019.1455
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2019;76(6):630. doi:10.1001/jamaneurol.2018.2992