This Viewpoint assesses the results of the Levodopa in Early Parkinson Disease trial with respect to the potential of levodopa as a disease-modifying intervention.
This Viewpoint discuss several tips and highlights the critical factors to help clinicians selecting the appropriate deep brain stimulation device for patients.
This randomized clinical trial compares the effects of mindfulness yoga vs conventional stretching and resistance training exercise on anxiety and depression in adults with idiopathic Parkinson disease in Hong Kong.
This secondary analysis of a randomized clinical trial investigates whether rivaroxaban is associated with a reduction in recurrent stroke among patients with embolic stroke of undetermined source who have an increased risk of atrial fibrillation.
This secondary analysis of a randomized clinical trial examines the short-term risk of hemorrhage in treating patients in North America, Europe, and Australasia with acute transient ischemic attack or minor acute ischemic stroke with clopidogrel plus aspirin or aspirin alone.
This cohort study examines the use of antiepileptic drugs and differences between valproate and topiramate prescribing in women of childbearing age with epilepsy.
This cohort study uses data from the Alzheimer’s Disease Neuroimaging Initiative study to examine whether plasma neurofilament light, a noninvasive biomarker measurement, is associated with other markers of Alzheimer disease and other measures of neurodegeneration in patients with Alzheimer disease.
This review of electrocorticographic recordings and clinical meta-data assesses seizure control in 12 patients with focal epilepsy who were treated with closed-loop invasive brain stimulation.
This case series study investigates the association between circulating cholesterol levels and early-onset Alzheimer disease and identifies genetic variants underlying any possible association in blood samples of patients with early-onset Alzheimer disease.
This cohort study combines long-standing community-based samples to examine the associations between cortical β-amyloid protein in the absence of insoluble deposits with cognitive decline, neurofibrillary tangles, other age-associated neuropathologic signs and symptoms, and APOE.
This nested case-control study uses a large primary care population database in the United Kingdom to analyze the relative and absolute risk estimates of peripheral neuropathy among adults issued prescriptions for oral fluoroquinolone or amoxicillin-clavulanate antibiotics.
This study examines the mechanism by which triptan drugs enter the central nervous system in individuals with migraine.
This cohort study of patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome assessed a possible association of intrathecal IgG synthesis and Expanded Disability Status Scale scores in the 4 years after diagnosis.
This meta-analysis examines 90-day mortality and 90-day intracranial hemorrhage reported in trials of endovascular thrombectomy vs medical therapy cited in the 2018 American Stroke Association/American Heart Association guidelines for acute ischemic stroke.
This narrative review examines the existing evidence of the differing response of embolic stroke of undetermined source to anticoagulation therapy and hypothesizes about pathophysiological factors that may underlie such variations.
This case report describes a woman with a drooping eyelid that appeared shortly after vomiting, which was caused by an unusual but nondangerous mechanism.
This study presents data regarding attitudes towards physician-assisted suicide from a survey of cognitively normal individuals enrolled in a clinical trial that required them to learn whether they have elevated amyloid-β.
This case study describes a patient in whom administration of an anti-CD20 antibody to treat multiple sclerosis appears to have precipitated liver failure.