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September 2019 - July 1959

Decade

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Issue

July 2019, Vol 76, No. 7, Pages 737-872

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2019;76(7):737. doi:10.1001/jamaneurol.2018.2996
Viewpoint

The Final Nail in the Coffin of Disease Modification for Dopaminergic Therapies: The LEAP Trial

Abstract Full Text
JAMA Neurol. 2019;76(7):747-748. doi:10.1001/jamaneurol.2019.0974

This Viewpoint assesses the results of the Levodopa in Early Parkinson Disease trial with respect to the potential of levodopa as a disease-modifying intervention.

Tips for Choosing a Deep Brain Stimulation Device

Abstract Full Text
JAMA Neurol. 2019;76(7):749-750. doi:10.1001/jamaneurol.2019.0849

This Viewpoint discuss several tips and highlights the critical factors to help clinicians selecting the appropriate deep brain stimulation device for patients.

Editorial

Apolipoprotein B as a New Link Between Cholesterol and Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2019;76(7):751-753. doi:10.1001/jamaneurol.2019.0212

On the Association Between Fluoroquinolones and Neuropathy

Abstract Full Text
JAMA Neurol. 2019;76(7):753-754. doi:10.1001/jamaneurol.2019.0886
Original Investigation

Effects of Mindfulness Yoga vs Stretching and Resistance Training Exercises on Anxiety and Depression for People With Parkinson Disease: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2019;76(7):755-763. doi:10.1001/jamaneurol.2019.0534

This randomized clinical trial compares the effects of mindfulness yoga vs conventional stretching and resistance training exercise on anxiety and depression in adults with idiopathic Parkinson disease in Hong Kong.

Recurrent Stroke With Rivaroxaban Compared With Aspirin According to Predictors of Atrial Fibrillation: Secondary Analysis of the NAVIGATE ESUS Randomized Clinical Trial

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(7):764-773. doi:10.1001/jamaneurol.2019.0617

This secondary analysis of a randomized clinical trial investigates whether rivaroxaban is associated with a reduction in recurrent stroke among patients with embolic stroke of undetermined source who have an increased risk of atrial fibrillation.

Risk for Major Hemorrhages in Patients Receiving Clopidogrel and Aspirin Compared With Aspirin Alone After Transient Ischemic Attack or Minor Ischemic Stroke: A Secondary Analysis of the POINT Randomized Clinical Trial

Abstract Full Text
has audio
JAMA Neurol. 2019;76(7):774-782. doi:10.1001/jamaneurol.2019.0932

This secondary analysis of a randomized clinical trial examines the short-term risk of hemorrhage in treating patients in North America, Europe, and Australasia with acute transient ischemic attack or minor acute ischemic stroke with clopidogrel plus aspirin or aspirin alone.

Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy

Abstract Full Text
JAMA Neurol. 2019;76(7):783-790. doi:10.1001/jamaneurol.2019.0447

This cohort study examines the use of antiepileptic drugs and differences between valproate and topiramate prescribing in women of childbearing age with epilepsy.

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2019;76(7):791-799. doi:10.1001/jamaneurol.2019.0765

This cohort study uses data from the Alzheimer’s Disease Neuroimaging Initiative study to examine whether plasma neurofilament light, a noninvasive biomarker measurement, is associated with other markers of Alzheimer disease and other measures of neurodegeneration in patients with Alzheimer disease.

Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy

Abstract Full Text
has active quiz
JAMA Neurol. 2019;76(7):800-808. doi:10.1001/jamaneurol.2019.0658

This review of electrocorticographic recordings and clinical meta-data assesses seizure control in 12 patients with focal epilepsy who were treated with closed-loop invasive brain stimulation.

Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB

Abstract Full Text
JAMA Neurol. 2019;76(7):809-817. doi:10.1001/jamaneurol.2019.0648

This case series study investigates the association between circulating cholesterol levels and early-onset Alzheimer disease and identifies genetic variants underlying any possible association in blood samples of patients with early-onset Alzheimer disease.

Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2019;76(7):818-826. doi:10.1001/jamaneurol.2019.0834

This cohort study combines long-standing community-based samples to examine the associations between cortical β-amyloid protein in the absence of insoluble deposits with cognitive decline, neurofibrillary tangles, other age-associated neuropathologic signs and symptoms, and APOE.

Association Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy

Abstract Full Text
JAMA Neurol. 2019;76(7):827-833. doi:10.1001/jamaneurol.2019.0887

This nested case-control study uses a large primary care population database in the United Kingdom to analyze the relative and absolute risk estimates of peripheral neuropathy among adults issued prescriptions for oral fluoroquinolone or amoxicillin-clavulanate antibiotics.

Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding

Abstract Full Text
JAMA Neurol. 2019;76(7):834-840. doi:10.1001/jamaneurol.2019.0755

This study examines the mechanism by which triptan drugs enter the central nervous system in individuals with migraine.

Association of Intrathecal Immunoglobulin G Synthesis With Disability Worsening in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2019;76(7):841-849. doi:10.1001/jamaneurol.2019.0905

This cohort study of patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome assessed a possible association of intrathecal IgG synthesis and Expanded Disability Status Scale scores in the 4 years after diagnosis.

Brief Report

Endovascular Thrombectomy as a Means to Improve Survival in Acute Ischemic Stroke: A Meta-analysis

Abstract Full Text
JAMA Neurol. 2019;76(7):850-854. doi:10.1001/jamaneurol.2019.0525

This meta-analysis examines 90-day mortality and 90-day intracranial hemorrhage reported in trials of endovascular thrombectomy vs medical therapy cited in the 2018 American Stroke Association/American Heart Association guidelines for acute ischemic stroke.

Review

Tailoring the Approach to Embolic Stroke of Undetermined Source: A Review

Abstract Full Text
JAMA Neurol. 2019;76(7):855-861. doi:10.1001/jamaneurol.2019.0591

This narrative review examines the existing evidence of the differing response of embolic stroke of undetermined source to anticoagulation therapy and hypothesizes about pathophysiological factors that may underlie such variations.

Images in Neurology

Drooping Eyelid After Vomiting

Abstract Full Text
JAMA Neurol. 2019;76(7):862-863. doi:10.1001/jamaneurol.2019.1417

This case report describes a woman with a drooping eyelid that appeared shortly after vomiting, which was caused by an unusual but nondangerous mechanism.

Research Letter

Attitudes Toward Physician-Assisted Death From Individuals Who Learn They Have an Alzheimer Disease Biomarker

Abstract Full Text
JAMA Neurol. 2019;76(7):864-866. doi:10.1001/jamaneurol.2019.0797

This study presents data regarding attitudes towards physician-assisted suicide from a survey of cognitively normal individuals enrolled in a clinical trial that required them to learn whether they have elevated amyloid-β.

Fulminant Hepatitis Associated With Echovirus 25 During Treatment With Ocrelizumab for Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2019;76(7):866-867. doi:10.1001/jamaneurol.2019.0522

This case study describes a patient in whom administration of an anti-CD20 antibody to treat multiple sclerosis appears to have precipitated liver failure.

Comment & Response

Autoantibodies at the Center of (sub)Classification—Issues of Detection

Abstract Full Text
JAMA Neurol. 2019;76(7):867-868. doi:10.1001/jamaneurol.2019.0440

Autoantibodies at the Center of (sub)Classification—Issues of Detection—Reply

Abstract Full Text
JAMA Neurol. 2019;76(7):868-869. doi:10.1001/jamaneurol.2019.0443

Laterality and Stimulation Bias in Meta-analysis of Placebo Responses

Abstract Full Text
JAMA Neurol. 2019;76(7):869-870. doi:10.1001/jamaneurol.2019.1229

Laterality and Stimulation Bias in Meta-analysis of Placebo Responses—Reply

Abstract Full Text
JAMA Neurol. 2019;76(7):870. doi:10.1001/jamaneurol.2019.1232

Absolute Risk Estimates of the Association Between Concussion and Suicide

Abstract Full Text
JAMA Neurol. 2019;76(7):870-871. doi:10.1001/jamaneurol.2019.1449

Absolute Risk Estimates of the Association Between Concussion and Suicide—Reply

Abstract Full Text
JAMA Neurol. 2019;76(7):871-872. doi:10.1001/jamaneurol.2019.1452
Correction

Error in Table

Abstract Full Text
free access
JAMA Neurol. 2019;76(7):872. doi:10.1001/jamaneurol.2019.1177

Error in Author Byline

Abstract Full Text
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JAMA Neurol. 2019;76(7):872. doi:10.1001/jamaneurol.2019.1501

Error in Abstract

Abstract Full Text
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JAMA Neurol. 2019;76(7):872. doi:10.1001/jamaneurol.2019.1649
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2019;76(7):738. doi:10.1001/jamaneurol.2018.2997
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