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August 2019, Vol 76, No. 8, Pages 877-986

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2019;76(8):877. doi:10.1001/jamaneurol.2018.3001
Viewpoint

Estimating Neurologic Prognosis in Children: High Stakes, Poor Data

Abstract Full Text
JAMA Neurol. 2019;76(8):879-880. doi:10.1001/jamaneurol.2019.1157

This Viewpoint describes the challenges and opportunities in estimating neurologic prognoses to inform families and encourages engaging families in outcomes development.

On the Brain

The Art of Caregiving: Lessons in Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2019;76(8):881-882. doi:10.1001/jamaneurol.2019.1599

This essay discusses lessons learned by being a caretaker for a grandparent with Alzheimer disease.

Editorial

Concussions and Dementia—Are Statins the Salve in the Wound?

Abstract Full Text
JAMA Neurol. 2019;76(8):883-884. doi:10.1001/jamaneurol.2019.0846

Status Epilepticus Mortality—Improving or Status Quo?

Abstract Full Text
JAMA Neurol. 2019;76(8):885-886. doi:10.1001/jamaneurol.2019.0844
Original Investigation

Association Between Statin Use and Risk of Dementia After a Concussion

Abstract Full Text
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JAMA Neurol. 2019;76(8):887-896. doi:10.1001/jamaneurol.2019.1148

This large extended population-based double cohort study tests whether statin use is associated with an increased or decreased risk of subsequent dementia after a concussion among older adults.

Change in Mortality of Generalized Convulsive Status Epilepticus in High-Income Countries Over Time: A Systematic Review and Meta-analysis

Abstract Full Text
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JAMA Neurol. 2019;76(8):897-905. doi:10.1001/jamaneurol.2019.1268

This systematic review and meta-analysis examines the change in convulsive status epilepticus–associated mortality among studies of adults and children in 17 countries..

Frequency of Intracranial Hemorrhage With Low-Dose Aspirin in Individuals Without Symptomatic Cardiovascular Disease: A Systematic Review and Meta-analysis

Abstract Full Text
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JAMA Neurol. 2019;76(8):906-914. doi:10.1001/jamaneurol.2019.1120

This systematic review and meta-analysis assesses the risk of intracranial hemorrhage associated with low-dose aspirin among individuals without symptomatic cardiovascular disease.

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study

Abstract Full Text
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JAMA Neurol. 2019;76(8):915-924. doi:10.1001/jamaneurol.2019.1424

This cohort study assesses the associations among amyloid-β, tau, and cognition, measured during different observation periods for 7 years.

Derivation and External Validation of a Scoring System for Predicting Fracture Risk After Ischemic Stroke in a Canadian Cohort

Abstract Full Text
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JAMA Neurol. 2019;76(8):925-931. doi:10.1001/jamaneurol.2019.1114

This prognostic study evaluated medical records of survivors of ischemic stroke from a national Canadian database to develop and validate a scoring system to predict low-trauma fractures within 1 year of hospital discharge.

Effect of a Quality Improvement Intervention on Adherence to Therapies for Patients With Acute Ischemic Stroke and Transient Ischemic Attack: A Cluster Randomized Clinical Trial

Abstract Full Text
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JAMA Neurol. 2019;76(8):932-941. doi:10.1001/jamaneurol.2019.1012

This cluster randomized clinical trial assesses the effect of a multifaceted quality improvement intervention compared with routine care on adherence to evidence-based therapy among patients with acute ischemic stroke and transient ischemic attack.

Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease

Abstract Full Text
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JAMA Neurol. 2019;76(8):942-948. doi:10.1001/jamaneurol.2019.1066

This gene-based transethnic meta-analysis combines data from community-based cohorts to find genetic variants associated with late-onset Alzheimer disease.

Association of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral Hemorrhage

Abstract Full Text
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JAMA Neurol. 2019;76(8):949-955. doi:10.1001/jamaneurol.2019.1141

This exploratory analysis of Antihypertensive Treatment of Acute Cerebral Hemorrhage–2 randomized clinical trial data seeks to determine whether intensive blood pressure reduction is associated with decreased risk of hematoma expansion in patients with intracerebral hemorrhage and if these associations are modified by the specific deep-brain nuclei involved.

Association Between Unrecognized Myocardial Infarction and Cerebral Infarction on Magnetic Resonance Imaging

Abstract Full Text
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JAMA Neurol. 2019;76(8):956-961. doi:10.1001/jamaneurol.2019.1226

This cross-sectional study of a cohort of the Age, Gene/Environment Susceptibility–Reykjavik Study determines whether unrecognized myocardial infarction detected by cardiac magnetic resonance imaging is associated with cerebral infarction.

Sex Differences in Presentation and Outcome After an Acute Transient or Minor Neurologic Event

Abstract Full Text
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JAMA Neurol. 2019;76(8):962-968. doi:10.1001/jamaneurol.2019.1305

This cohort study assesses whether sex differences exist in symptoms, diagnoses, or outcomes among patients presenting with acute transient or minor neurologic events at multicenter academic emergency departments in Canada.

Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease

Abstract Full Text
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JAMA Neurol. 2019;76(8):969-977. doi:10.1001/jamaneurol.2019.1071

This longitudinal cohort study assesses whether plasma and cerebrospinal fluid biomarkers are associated with survival time in sporadic Creutzfeldt-Jakob disease.

Special Communication

Maximizing the Benefit of Life-Saving Treatments for Pompe Disease, Spinal Muscular Atrophy, and Duchenne Muscular Dystrophy Through Newborn Screening: Essential Steps

Abstract Full Text
JAMA Neurol. 2019;76(8):978-983. doi:10.1001/jamaneurol.2019.1206

This Special Communication discusses challenges to implementing newborn screening for neuromuscular diseases and how overcoming those challenges can maximize the potential of newly available life-saving therapies.

Comment & Response

Inclusivity of Diverse Patient Groups

Abstract Full Text
JAMA Neurol. 2019;76(8):984. doi:10.1001/jamaneurol.2019.1374

Inclusivity of Diverse Patient Groups—Reply

Abstract Full Text
JAMA Neurol. 2019;76(8):984-985. doi:10.1001/jamaneurol.2019.1390

Dancing Dorsal Quadrilaterals—Organic or Functional?

Abstract Full Text
JAMA Neurol. 2019;76(8):985. doi:10.1001/jamaneurol.2019.1717

Dancing Dorsal Quadrilaterals—Organic or Functional?—Reply

Abstract Full Text
JAMA Neurol. 2019;76(8):985-986. doi:10.1001/jamaneurol.2019.1720
Correction

Error in Table 1

Abstract Full Text
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JAMA Neurol. 2019;76(8):986. doi:10.1001/jamaneurol.2019.1257

Error in In-Text Citations

Abstract Full Text
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JAMA Neurol. 2019;76(8):986. doi:10.1001/jamaneurol.2019.1298

Errors in Table 2 and Table 3

Abstract Full Text
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JAMA Neurol. 2019;76(8):986. doi:10.1001/jamaneurol.2019.1965

Error in Figure 3

Abstract Full Text
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JAMA Neurol. 2019;76(8):986. doi:10.1001/jamaneurol.2019.2144
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2019;76(8):878. doi:10.1001/jamaneurol.2018.3002
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