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September 2019 - July 1959

Decade

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Issue

September 2019, Vol 76, No. 9, Pages 995-1124

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2019;76(9):995. doi:10.1001/jamaneurol.2018.3006
Viewpoint

The Dilemma of Diagnosing Idiopathic Intracranial Hypertension Without Papilledema in Patients With Chronic Migraine

Abstract Full Text
JAMA Neurol. 2019;76(9):1001-1002. doi:10.1001/jamaneurol.2019.1696

This Viewpoint discusses the management of idiopathic intracranial hypertension without papilledema in patients with chronic migraine.

Autopsy Analyses in Neurological Drug Development—Opening the Black Box

Abstract Full Text
JAMA Neurol. 2019;76(9):1003-1004. doi:10.1001/jamaneurol.2019.2265

This Viewpoint explores the incorporation of autopsy analyses into neurology drug clinical trials and discusses their use as well as barriers to implementation and potential solutions.

On the Brain

Why Do You Want to Be a Physician?

Abstract Full Text
JAMA Neurol. 2019;76(9):1005. doi:10.1001/jamaneurol.2019.1824

This essay describes a standard question from medical school interviews that first annoyed and then held special insight for the author.

Editorial

Is Interferon Therapy for Hepatitis C Infection a Treatable Risk Factor for Parkinson Disease?

Abstract Full Text
JAMA Neurol. 2019;76(9):1006-1007. doi:10.1001/jamaneurol.2019.1377

Long-term Cognitive Consequences for Patients With Pediatric-Onset Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2019;76(9):1008-1009. doi:10.1001/jamaneurol.2019.0847

Blood Biomarkers for Use in Alzheimer Disease—Moving From “If” to “How?”

Abstract Full Text
JAMA Neurol. 2019;76(9):1009-1010. doi:10.1001/jamaneurol.2019.0845
Original Investigation

Association of Antiviral Therapy With Risk of Parkinson Disease in Patients With Chronic Hepatitis C Virus Infection

Abstract Full Text
free access has active quiz
JAMA Neurol. 2019;76(9):1019-1027. doi:10.1001/jamaneurol.2019.1368

This cohort study uses claims data and diagnostic coding in a large national database of Taiwanese patients to identify the association between the hepatitis C virus, treatment regimens for this infection, and Parkinson disease prescriptions.

Long-term Cognitive Outcomes in Patients With Pediatric-Onset vs Adult-Onset Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2019;76(9):1028-1034. doi:10.1001/jamaneurol.2019.1546

This cohort study compares long-term information-processing efficiency between patients with pediatric-onset and adult-onset multiple sclerosis in Sweden.

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2019;76(9):1035-1048. doi:10.1001/jamaneurol.2019.1534

This systematic review and meta-analysis assesses the associations of age, sex, and diagnosis with neurofilament light in cerebrospinal fluid and evaluates its potential in discriminating clinically similar conditions.

Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study

Abstract Full Text
JAMA Neurol. 2019;76(9):1049-1059. doi:10.1001/jamaneurol.2019.1313

This cohort study examines the physical and neuropsychological outcomes in patients with mild traumatic brain injury up to 12 months after presentation.

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease–Related β-Amyloid Status

Abstract Full Text
open access
JAMA Neurol. 2019;76(9):1060-1069. doi:10.1001/jamaneurol.2019.1632

This corss-sectional diagnostic study evaluates the accuracy of fully automated plasma assays in measuring plasma β-amyloid and tau in patients with and without cognitive impairment in the Swedish BioFINDER study and an independent validation cohort.

Association of Cortical Stimulation–Induced Seizure With Surgical Outcome in Patients With Focal Drug-Resistant Epilepsy

Abstract Full Text
JAMA Neurol. 2019;76(9):1070-1078. doi:10.1001/jamaneurol.2019.1464

This cohort study examines the cortical stimulation of the epileptogenic zone and its association with good or poor outcomes in patients with focal epilepsy.

Efficacy of Home-Based Telerehabilitation vs In-Clinic Therapy for Adults After Stroke: A Randomized Clinical Trial

Abstract Full Text
has audio
JAMA Neurol. 2019;76(9):1079-1087. doi:10.1001/jamaneurol.2019.1604

This randomized clinical trial examines whether a treatment targeting arm movement delivered via a home-based telerehabilitation system has comparable efficacy with dose-matched, intensity-matched therapy delivered in a traditional in-clinic setting for adults following stroke.

Association Between Idiopathic Intracranial Hypertension and Risk of Cardiovascular Diseases in Women in the United Kingdom

Abstract Full Text
open access has active quiz
JAMA Neurol. 2019;76(9):1088-1098. doi:10.1001/jamaneurol.2019.1812

This study analyzes the electronic medical records stored in The Health Improvement Network database of UK women with idiopathic intracranial hypertension to identify their cardiometabolic risks and outcomes.

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

Abstract Full Text
JAMA Neurol. 2019;76(9):1099-1108. doi:10.1001/jamaneurol.2019.1456

This case-control study evaluates APOE associations with variants, using whole-exome sequencing, in participants with and without APOE ε4 alleles.

Review

Tackling Epilepsy With High-definition Precision Medicine: A Review

Abstract Full Text
JAMA Neurol. 2019;76(9):1109-1116. doi:10.1001/jamaneurol.2019.2384

This narrative review describes precision medicine derived from research that uses cellular and animal models to define the genetic factors that underlie various types of epilepsy.

Images in Neurology

Combined Cerebral Microbleeds With Lacunar Infarctions in Familial Cerebral Cavernous Malformations

Abstract Full Text
JAMA Neurol. 2019;76(9):1117-1118. doi:10.1001/jamaneurol.2019.1980

This case report describes a 62-year-old man who presented with dizziness, right-sided numbness, and mild weakness for 10 days.

JAMA Neurology Clinical Challenge

A Case of Muscle Twitching With Psoriasis

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2019;76(9):1119-1120. doi:10.1001/jamaneurol.2019.1937

A 42-year-old man presents with a 2-month history of persistent muscle twitching in his abdomen and bilateral calves during wakefulness and sleep accompanied with excessive sweating, as well as mild bilateral lower extremity weakness after prolonged walking. What is your diagnosis?

Research Letter

Association Between Food Insecurity and Migraine Among US Young Adults

Abstract Full Text
JAMA Neurol. 2019;76(9):1121-1122. doi:10.1001/jamaneurol.2019.1663

This study examines the association between food insecurity and migraine in a nationally representative sample of US young adults.

Comparison of Attention for Neurological Research on Social Media vs Academia: An Altmetric Score Analysis

Abstract Full Text
JAMA Neurol. 2019;76(9):1122-1124. doi:10.1001/jamaneurol.2019.1791

This study compared Altmetric scores of neurological research as a marker of “buzz” with citations as a marker of academic attention.

Comment & Response

Dysregulation of the Reward and Learning Systems in Tourette Syndrome

Abstract Full Text
JAMA Neurol. 2019;76(9):1124. doi:10.1001/jamaneurol.2019.2027
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2019;76(9):997. doi:10.1001/jamaneurol.2018.3007
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