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January 2020 - July 1959




January 2020, Vol 77, No. 1, Pages 1-135

In This Issue of JAMA Neurology


Abstract Full Text
free access
JAMA Neurol. 2020;77(1):1. doi:10.1001/jamaneurol.2019.3178

Mendelian Randomization—A Journey From Obscurity to Center Stage With a Few Potholes Along the Way

Abstract Full Text
JAMA Neurol. 2020;77(1):7-8. doi:10.1001/jamaneurol.2019.3419

This Viewpoint discusses why mendelian randomization is useful, pitfalls of this method, and why it has recently gained popularity with the help of genome-wide association studies.

Are Daylight Saving Time Changes Bad for the Brain?

Abstract Full Text
JAMA Neurol. 2020;77(1):9-10. doi:10.1001/jamaneurol.2019.3780

This Viewpoint reviews data associated with the US daylight saving time transition.

On the Brain

The Patient I Didn’t Like

Abstract Full Text
JAMA Neurol. 2020;77(1):11-12. doi:10.1001/jamaneurol.2019.3899

This essay describes lessons the author learned through treating a difficult patient.


Endovascular Therapy for Childhood Stroke—Working Together to Reach Prime Time

Abstract Full Text
JAMA Neurol. 2020;77(1):13-15. doi:10.1001/jamaneurol.2019.3412
Original Investigation

Medical Management vs Mechanical Thrombectomy for Mild Strokes: An International Multicenter Study and Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2020;77(1):16-24. doi:10.1001/jamaneurol.2019.3112

This pooled analysis and meta-analysis assesses the outcomes of patients with mild-deficits mild emergency large-vessel occlusion treated with mechanical thrombectomy vs best medical management.

Feasibility, Safety, and Outcome of Endovascular Recanalization in Childhood Stroke: The Save ChildS Study

Abstract Full Text
JAMA Neurol. 2020;77(1):25-34. doi:10.1001/jamaneurol.2019.3403

This cohort study examines the use of endovascular recanalization in pediatric patients with arterial ischemic stroke and clinical outcomes.

Association of Cavum Septum Pellucidum and Cavum Vergae With Cognition, Mood, and Brain Volumes in Professional Fighters

Abstract Full Text
has active quiz
JAMA Neurol. 2020;77(1):35-42. doi:10.1001/jamaneurol.2019.2861

This cohort study examines the association of brain structure volume with cognitive and mood test scores among boxers and mixed martial arts fighters with cavum septum pellucidum and cavum vergae.

Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes: A Secondary Analysis of the COMPASS Trial

Abstract Full Text
JAMA Neurol. 2020;77(1):43-48. doi:10.1001/jamaneurol.2019.2984

This secondary analysis of a multinational randomized clinical trial of 27 395 participants with systemic atherosclerotic disease examines the association low-dose rivaroxaban plus aspirin, rivaroxaban alone, or aspirin alone and the risk of different ischemic stroke subtypes.

Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms

Abstract Full Text
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JAMA Neurol. 2020;77(1):49-57. doi:10.1001/jamaneurol.2019.3531

This study assesses the reliability of subspecialty-trained clinical neurophysiologists in detecting interictal epileptiform discharges in routine electroencephalograms (EEGs) recorded from 2012 to 2016.

Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2020;77(1):58-64. doi:10.1001/jamaneurol.2019.3238

This nested case-control study evaluates the levels of serum neurofilament light chain in presymptomatic individuals with multiple sclerosis to determine a prodromal phase of the disease.

Association Between Post–Dural Puncture Headache After Neuraxial Anesthesia in Childbirth and Intracranial Subdural Hematoma

Abstract Full Text
JAMA Neurol. 2020;77(1):65-72. doi:10.1001/jamaneurol.2019.2995

This cohort study assesses the association of post–dural puncture headache with postpartum intracranial subdural hematoma in women whose data were in the US Agency for Healthcare Research and Quality National Readmission Database.

Developmental Trajectories of Infants With Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study

Abstract Full Text
JAMA Neurol. 2020;77(1):73-81. doi:10.1001/jamaneurol.2019.3341

This cohort study compares outcomes and trajectories associated with varying familial risk for autism spectrum disorder across the first 3 years of life in siblings of children with autism spectrum disorder.

Serial Anti–Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes

Abstract Full Text
open access
JAMA Neurol. 2020;77(1):82-93. doi:10.1001/jamaneurol.2019.2940

This cohort study characterizes serial anti–myelin oligodendrocyte glycoprotein antibody serologies and clinical and imaging features both at presentation and during follow-up in children with acquired demyelination syndromes.

Progressive Multifocal Leukoencephalopathy Incidence and Risk Stratification Among Natalizumab Users in France

Abstract Full Text
has active quiz
JAMA Neurol. 2020;77(1):94-102. doi:10.1001/jamaneurol.2019.2670

This study uses a French multiple sclerosis cohort to examine the risk of developing progressive multifocal leukoencephalopathy before and after the release of nationwide risk-minimization recommendations among people with multiple sclerosis who used natalizumab.

Brief Report

Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation

Abstract Full Text
JAMA Neurol. 2020;77(1):103-108. doi:10.1001/jamaneurol.2019.3485

This diagnostic study aims to evaluate and validate a deep neural network trained to detect epileptiform discharges during electroencephalogram interpretation in comparison with expert physicians with subspecialty training.

Trends in Stroke Incidence Rates in Older US Adults: An Update From the Atherosclerosis Risk in Communities (ARIC) Cohort Study

Abstract Full Text
JAMA Neurol. 2020;77(1):109-113. doi:10.1001/jamaneurol.2019.3258

This cohort study evaluates whether stroke incidence declined among older adults from 1987 to 2011 vs 2011 to 2017 in the Atherosclerosis Risk in Communities study.


The Hazard of Negative (Not Neutral) Trials on Treatment of Acute Stroke: A Review

Abstract Full Text
JAMA Neurol. 2020;77(1):114-124. doi:10.1001/jamaneurol.2019.4107

This narrative review summarizes randomized clinical trials with negative (vs neutral) outcomes to study why previous acute stroke interventions appeared to cause harm.

Images in Neurology

Distinctive Magnetic Resonance Imaging Findings in IgLON5 Antibody Disease

Abstract Full Text
JAMA Neurol. 2020;77(1):125-126. doi:10.1001/jamaneurol.2019.3638

This case report describes distinctive magnetic resonance imaging findings in a Chinese woman with IgLON5 antibody disease.

Developmental Venous Anomaly Inside a Glioblastoma

Abstract Full Text
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JAMA Neurol. 2020;77(1):127-128. doi:10.1001/jamaneurol.2019.3840

This case report details an unusual developmental venous anomaly within a glioblastoma.

JAMA Neurology Clinical Challenge

Pyogenic Brain Abscesses in a Patient With Digital Clubbing

Abstract Full Text
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JAMA Neurol. 2020;77(1):129-130. doi:10.1001/jamaneurol.2019.3327

A man presents with headache, double vision, and seizures for 1 month. Cranial magnetic resonance imaging showed 2 ring-enhancing brain lesions with thin-walled, contrast-enhancing rims and central liquefaction. What is your diagnosis?

A Rare Form of Lipid Metabolic Encephalopathy

Abstract Full Text
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JAMA Neurol. 2020;77(1):131-132. doi:10.1001/jamaneurol.2019.3551

A 27-year-old Asian man was found with painless masses of about 5.1 cm in diameter that appeared on both Achilles tendons 10 years ago. What is your diagnosis?

Comment & Response

Left Atrial Enlargement Could Be Detected on Extended Computed Tomography Angiography Within Initial Stroke Assessment

Abstract Full Text
JAMA Neurol. 2020;77(1):134. doi:10.1001/jamaneurol.2019.3791

Left Atrial Enlargement Could Be Detected on Extended Computed Tomography Angiography Within Initial Stroke Assessment—Reply

Abstract Full Text
JAMA Neurol. 2020;77(1):134-135. doi:10.1001/jamaneurol.2019.3794

Incomplete Author Name and Credentials in Byline

Abstract Full Text
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JAMA Neurol. 2020;77(1):135. doi:10.1001/jamaneurol.2019.4541
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2020;77(1):2. doi:10.1001/jamaneurol.2019.3179