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June 2021 - July 1959

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October 2020, Vol 77, No. 10, Pages 1200-1322

Viewpoint

Stroke Thrombolysis With Tenecteplase to Reduce Emergency Department Spread of Coronavirus Disease 2019 and Shortages of Alteplase

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JAMA Neurol. 2020;77(10):1203-1204. doi:10.1001/jamaneurol.2020.2396

This Viewpoint advocates for expanded usage of tenecteplase in patients with stroke as a means of avoiding coronavirus disease 2019 spread and easing potential shortages of alteplase.

On the Brain

Any Recent Stressors?—A Memoir of Transient Global Amnesia

Abstract Full Text
JAMA Neurol. 2020;77(10):1205-1206. doi:10.1001/jamaneurol.2020.1403

This essay describes the author’s experience with transient global amnesia and the treatment he received as a patient.

Editorial

Modifiable Lifestyle Factors in Alzheimer Disease: An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration

Abstract Full Text
JAMA Neurol. 2020;77(10):1207-1209. doi:10.1001/jamaneurol.2020.1114

Should Neurologists Be Concerned With REM Sleep Quantity?

Abstract Full Text
JAMA Neurol. 2020;77(10):1209-1210. doi:10.1001/jamaneurol.2020.2122

Continuous Electroencephalogram—Necessity or Luxury?

Abstract Full Text
JAMA Neurol. 2020;77(10):1211-1212. doi:10.1001/jamaneurol.2020.1483
Original Investigation

Association of Early-Life Cognitive Enrichment With Alzheimer Disease Pathological Changes and Cognitive Decline

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JAMA Neurol. 2020;77(10):1217-1224. doi:10.1001/jamaneurol.2020.1941

This cohort study examines the association of early-life cognitive enrichment with late-life Alzheimer disease and other common dementia-related pathological changes in an autopsy sample.

Continuous vs Routine Electroencephalogram in Critically Ill Adults With Altered Consciousness and No Recent Seizure: A Multicenter Randomized Clinical Trial

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JAMA Neurol. 2020;77(10):1225-1232. doi:10.1001/jamaneurol.2020.2264

This randomized clinical trial investigates whether continuous electroencephalogram is associated with reduced mortality compared with routine electroencephalogram.

Characteristics of Recurrent Ischemic Stroke After Embolic Stroke of Undetermined Source: Secondary Analysis of a Randomized Clinical Trial

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JAMA Neurol. 2020;77(10):1233-1240. doi:10.1001/jamaneurol.2020.1995

This secondary analysis of a randomized clinical trial assesses the subtype of recurrent ischemic stroke after embolic stroke of underdetermined source, the interaction with treatment assignment, and the consistency of cerebral location of the qualifying and recurrent strokes in the study population of the NAVIGATE-ESUS trial.

Association of Rapid Eye Movement Sleep With Mortality in Middle-aged and Older Adults

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JAMA Neurol. 2020;77(10):1241-1251. doi:10.1001/jamaneurol.2020.2108

This cross-sectional study investigates whether rapid eye movement sleep is associated with greater risk of mortality in 2 independent cohorts and explores whether another sleep stage could be driving these findings.

Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016

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JAMA Neurol. 2020;77(10):1252-1260. doi:10.1001/jamaneurol.2020.1512

This cohort study examines data from original and offspring participants in the Framingham Heart Study to assess the incidence of intracerebral hemorrhage, incidence rates stratified by deep and lobar brain locations, and location-specific risk factors between 1948 and 2016.

Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy–Related Inflammation

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JAMA Neurol. 2020;77(10):1261-1269. doi:10.1001/jamaneurol.2020.1782

This cohort study examines the clinical, neuroimaging, laboratory, pathologic, or treatment-related associations with outcomes after an episode of cerebral amyloid angiopathy-related inflammation.

Association of Circadian Abnormalities in Older Adults With an Increased Risk of Developing Parkinson Disease

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JAMA Neurol. 2020;77(10):1270-1278. doi:10.1001/jamaneurol.2020.1623

This cohort study assesses the association between rest-activity rhythm and risk of incident Parkinson disease and explores whether this association is independent of nighttime sleep disturbances in community-dwelling older men.

Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials: A Population-Based Study and Systematic Review

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JAMA Neurol. 2020;77(10):1279-1287. doi:10.1001/jamaneurol.2020.1948

This systematic review and meta-analysis examines the recurrence of ischemic stroke and possible use of patent foramen ovale closure in patients aged 60 years or older.

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease

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JAMA Neurol. 2020;77(10):1288-1298. doi:10.1001/jamaneurol.2020.1760

This genetic association study examines amyloid levels through positron emission tomographic imaging in individuals with or at risk for Alzheimer disease.

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults

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JAMA Neurol. 2020;77(10):1299-1307. doi:10.1001/jamaneurol.2020.1741

This cohort study examines brain autopsy data for the presence of quadruple misfolded proteins (tau, amyloid-β, α-synuclein, and transactive response DNA-binding protein 43) and their association with cognitive decline in older adults.

Review

New Horizons in Pharmacologic Therapy for Secondary Stroke Prevention

Abstract Full Text
JAMA Neurol. 2020;77(10):1308-1317. doi:10.1001/jamaneurol.2020.2494

This narrative review summarizes the results of recent and ongoing randomized clinical trials of drugs for secondary stroke prevention.

Images in Neurology

A Case of Topical Metronidazole–Induced Encephalopathy

Abstract Full Text
JAMA Neurol. 2020;77(10):1318-1319. doi:10.1001/jamaneurol.2020.2596

This case report describes a man who applied topical metronidazole to his decubitus ulcers and experienced an uncommon neurological complication.

Spontaneous Intracranial Hypotension With Brain Sagging Attributable to a Cerebrospinal Fluid–Venous Fistula

Abstract Full Text
JAMA Neurol. 2020;77(10):1320-1321. doi:10.1001/jamaneurol.2020.2372

This case report describes a 44-year-old man who presented with positional headaches and other symptoms and was found to have spontaneous intracranial hypotension because of a cerebrospinal fluid–venous fistula.

Correction

Error in Abstract

Abstract Full Text
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JAMA Neurol. 2020;77(10):1322. doi:10.1001/jamaneurol.2020.3067

Correction to Author’s Name in Byline

Abstract Full Text
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JAMA Neurol. 2020;77(10):1322. doi:10.1001/jamaneurol.2020.3444
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2020;77(10):1200. doi:10.1001/jamaneurol.2019.3224
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