This Viewpoint describes the clinical and public health implications of emerging information on subclinical cases of cerebrovascular disease.
This Viewpoint encourages researchers to take the opportunity to investigate brain adaptation to long-term spaceflight as a model of aging.
This essay describes an interaction the author had with a patient’s family members in deciding whether to pursue surgey for the patient.
This randomized clinical trial examines whether 24 months of minocycline treatment can modify cognitive and functional decline in patients with mild Alzheimer disease.
This longitudinal cohort study assesses the associations between vascular risk in early adulthood, midlife, and late life with late-life brain structure and β-amyloid load and white matter hyperintensity, whole-brain, and hippocampal volumes.
This registry-based cohort study examines the risk of serious infections associated with disease-modifying treatments for multiple sclerosis in Sweden.
This systematic review and meta-analysis assesses the association of bipolar disorder with a later diagnosis of idiopathic Parkinson disease.
The AMARANTH and DAYBREAK-ALZ randomized clinical trials assess whether lanabecestat slows the progression of Alzheimer disease compared with placebo in patients with early Alzheimer disease or mild Alzheimer disease dementia.
This prospective cohort study examines the association between seropositivity to Borrelia burgdorferi and incidental neuropsychiatric disorders and functional decline in rural southwestern France.
This parallel-design, double-blind randomized clinical trial assesses the safety, tolerability, and pharmacodynamics of the microtubule stabilizer TPI-287 in patients with Alzheimer disease or the 4-repeat tauopathies progressive supranuclear palsy and corticobasal syndrome.
This cross-sectional study using tissue from the Florida Autopsied Multi-Ethnic cohort assesses whether an association exists between neuropathologic subtypes of Alzheimer disease and neurofibrillary tangle accumulation or neuron loss in the nucleus basalis of Meynert, a major source of brain cholinergic innervation.
This cohort study comprehensively assesses key biological and methodologic aspects of trials of acute optic neuritis for testing neuroprotection and remyelination in multiple sclerosis.
This narrative review discusses the risk for and progression of multiple sclerosis in association with cigarette smoking.
This case report describes a man with recurrent attacks of yawning and fatigue that were mediated by dopamine and responsive to opioid treatment.
This case report describes CRMP5-IgG–associated paraneoplastic myelopathy with PD-L1 inhibitor therapy in a woman in her 60s.
This study characterizes the frequency and sex ratio of positive test results for myelin oligodendrocyte glycoprotein–IgG and aquaporin-4–IgG in adult and pediatric patient populations in a single center.
This study examines the perception of US individuals about their likelihood of developing dementia and their strategies to improve or maintain memory.
This cohort study uses Medicare data to examine the incidence and prevalence of Alzheimer disease and all forms of dementia in individuals with Down syndrome.