This Viewpoint describes freezing of gait in Parkinson disease, its association with long-term levodopa use, underlying pathophysiology, and options for improvements to clinical care.
This Viewpoint argues that there is a possibility of finding a path forward in Alzheimer disease prevention with the DNA amyloid β 1-42 timer vaccine that warrants its evaluation in a clinical trial.
This article describes the case of a juvenile Peruvian talking bear and discusses how it might be used to help medical students overcome neurophobia.
This randomized clinical trial investigates whether fenfluramine reduced monthly convulsive seizure frequency relative to placebo in patients with Dravet syndrome who were already taking stiripentol-inclusive regimens.
This randomized clinical trial evaluates the efficacy and safety of nilotinib hydrochloride for use in treatment of patients with Parkinson disease.
This cohort study assesses whether administration of intra-arterial urokinase is safe and improves reperfusion among patients who have undergone failed or incomplete mechanical thrombectomy.
This systematic review and meta-analysis examines the occurrence of multiple sclerosis relapses in women who are breastfeeding
This single-center observational cohort study aims to comprehensively characterize the spatiotemporal changes in cerebral physiology after traumatic brain injury by comparing a cohort of affected patients with healthy control participants.
This cross-sectional study examines the association between intracranial atherosclerotic disease and cerebral β-amyloid deposition in adults without dementia enrolled in the Atherosclerosis Risk in Communities Study.
This study investigates the potential association between tuberous sclerosis–associated neuropsychiatric disorders and frontotemporal dementia.
This systematic review and meta-analysis examines prognostic factors in c9 amyotrophic lateral sclerosis, c9 frontotemporal dementia, c9 amyotrophic lateral sclerosis and frontotemporal dementia, and atypical phenotypes.
This cohort study defines the distinguishing features of progressive supranuclear palsy and corticobasal syndrome and assesses their usefulness in facilitating early diagnosis and separation from Parkinson disease among patients with atypical parkinsonian syndromes.
This case report describes a 65-year-old woman with a right-hemispheric ischemic stroke in the territory of the middle cerebral artery along with left-sided hemiparesis with dysarthria and left-sided visual hemineglect.
This guideline summary provides a review of the American Academy of Neurology and the American Headache Society’s guidelines on Acute Treatment of Migraine in Children and Adolescents and Pharmacologic Treatment for Pediatric Migraine Prevention.
This case series describes 3 individuals with episodic visual snow, co-occurring with migraines.