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April 2020 - July 1959

Decade

Year

Issue

April 2020, Vol 77, No. 4, Pages 403-527

Viewpoint

Will We Ever Make Headway in Severe Traumatic Brain Injury Treatment Trials?

Abstract Full Text
JAMA Neurol. 2020;77(4):411-412. doi:10.1001/jamaneurol.2019.4672

This Viewpoint describes opportunities for improving research output on severe traumatic brain injury.

Rescuing Research Participants After Alzheimer Trials Stop Early: Sending Out an SOS

Abstract Full Text
JAMA Neurol. 2020;77(4):413-414. doi:10.1001/jamaneurol.2019.4974

This article documents the early endings of randomized clinical trials and their adverse effects on trial participants.

On the Brain

Teetering

Abstract Full Text
JAMA Neurol. 2020;77(4):415-416. doi:10.1001/jamaneurol.2019.4925

This essay describes a medical student’s experience caring for her grandmother.

Editorial

New Insights Into the APOE ε4–Soccer Heading Interaction: Handle With Care

Abstract Full Text
JAMA Neurol. 2020;77(4):417-418. doi:10.1001/jamaneurol.2019.4451
Original Investigation

Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players

Abstract Full Text
has audio
JAMA Neurol. 2020;77(4):419-426. doi:10.1001/jamaneurol.2019.4828

This cross-sectional study examines whether the apolipoprotein E ε4 allele and 12-month ball heading exposure are associated with verbal memory in a cohort of adult amateur soccer players.

Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial

Abstract Full Text
open access
JAMA Neurol. 2020;77(4):427-434. doi:10.1001/jamaneurol.2019.4611

This single-center open-label nonrandomized, noncontrolled trial assesses the safety, tolerability, cerebrospinal fluid penetration, and biochemical changes associated with ambroxol therapy for the treatment of patients with Parkinson disease with and without mutations in the glucocerebrosidase gene.

Association of Time Since Injury to the First Clinic Visit With Recovery Following Concussion

Abstract Full Text
has active quiz
JAMA Neurol. 2020;77(4):435-440. doi:10.1001/jamaneurol.2019.4552

This cross-sectional study investigates the association of the time from a sports injury to the initiation of clinical care with recovery time after concussion in adolescents and young adults.

Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy

Abstract Full Text
has active quiz
JAMA Neurol. 2020;77(4):441-450. doi:10.1001/jamaneurol.2019.4443

This cohort study aims to provide direct, objective information on infants’ antiepileptic drug exposure through breast milk.

Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume

Abstract Full Text
JAMA Neurol. 2020;77(4):451-460. doi:10.1001/jamaneurol.2019.4501

This cross-sectional study examines whether neighborhood-level socioeconomic disadvantage is associated with decreased brain volume in a cognitively unimpaired population enriched for Alzheimer disease risk.

Safety and Efficacy of RimabotulinumtoxinB for Treatment of Sialorrhea in Adults: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2020;77(4):461-469. doi:10.1001/jamaneurol.2019.4565

This randomized clinical trial evaluates the safety and efficacy of rimabotulinumtoxinB injections in the management of sialorrhea in adults.

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β

Abstract Full Text
open access
JAMA Neurol. 2020;77(4):470-479. doi:10.1001/jamaneurol.2019.4421

This study investigates whether apolipoprotein E ε4 is associated with medial temporal tau pathology independently of amyloid-β, sex, clinical status, and age.

Development and Validation of the Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS)

Abstract Full Text
JAMA Neurol. 2020;77(4):480-488. doi:10.1001/jamaneurol.2019.4490

This study describes the development and validation of a new self-reported amyotrophic lateral sclerosis disability scale.

Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury

Abstract Full Text
JAMA Neurol. 2020;77(4):489-499. doi:10.1001/jamaneurol.2019.4476

This multicenter cohort study assesses the association between spreading depolarizations in the brains of individuals who have undergone surgery for traumatic brain injury and neurologic outcomes.

Assessment of the Validity of the 2HELPS2B Score for Inpatient Seizure Risk Prediction

Abstract Full Text
JAMA Neurol. 2020;77(4):500-507. doi:10.1001/jamaneurol.2019.4656

This study assesses the validity of the 2HELPS2B score in predicting risk for electrographic seizures among patients undergoing electroencephalogram.

Characterization of Alzheimer Disease Biomarker Discrepancies Using Cerebrospinal Fluid Phosphorylated Tau and AV1451 Positron Emission Tomography

Abstract Full Text
JAMA Neurol. 2020;77(4):508-516. doi:10.1001/jamaneurol.2019.4749

This study characterizes individuals in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data set with tau abnormality indicated by cerebrospinal fluid assay or positron emission tomography.

Brief Report

Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy

Abstract Full Text
JAMA Neurol. 2020;77(4):517-521. doi:10.1001/jamaneurol.2019.4509

This case report compares in vivo 18F-flortaucipir at positron emission tomography with regions of tau pathology found at postmortem analysis in a former US football player with pathologically confirmed chronic traumatic encephalopathy.

Images in Neurology

Adrenomyeloneuropathy Masquerading as Chronic Myelitis

Abstract Full Text
JAMA Neurol. 2020;77(4):522-523. doi:10.1001/jamaneurol.2020.0019

This case report describes a mother and son who both experienced adrenomyeloneuropathy associated with ABCD1 mutation, despite a lack of typical test results.

Comment & Response

Premature Mortality in Epilepsy—A Reminder for the Untreated Millions

Abstract Full Text
JAMA Neurol. 2020;77(4):525. doi:10.1001/jamaneurol.2019.5091

Premature Mortality in Epilepsy—A Reminder for the Untreated Millions—Reply

Abstract Full Text
JAMA Neurol. 2020;77(4):525-526. doi:10.1001/jamaneurol.2019.5094

We Dropped the Reflex Hammer on Hypertension 20 Years Ago

Abstract Full Text
JAMA Neurol. 2020;77(4):526. doi:10.1001/jamaneurol.2020.0070

We Dropped the Reflex Hammer on Hypertension 20 Years Ago—Reply

Abstract Full Text
JAMA Neurol. 2020;77(4):526-527. doi:10.1001/jamaneurol.2020.0083
Correction

Errors in Text, Figures, and Author Affiliation

Abstract Full Text
free access
JAMA Neurol. 2020;77(4):527. doi:10.1001/jamaneurol.2020.0044

Error in Second Footnote to Table 2

Abstract Full Text
free access
JAMA Neurol. 2020;77(4):527. doi:10.1001/jamaneurol.2020.0054

Error in Author’s Name

Abstract Full Text
free access
JAMA Neurol. 2020;77(4):527. doi:10.1001/jamaneurol.2020.0140
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2020;77(4):403. doi:10.1001/jamaneurol.2019.3194
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