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February 2023 - July 1959




July 2020, Vol 77, No. 7, Pages 783-907


White Matter Degeneration—A Treatable Target?

Abstract Full Text
JAMA Neurol. 2020;77(7):793-794. doi:10.1001/jamaneurol.2020.0814

This Viewpoint discusses white matter degeneration as a potentially treatable target for reducing cognitive impairment and dementia.

On the Brain

Check Engine Light

Abstract Full Text
JAMA Neurol. 2020;77(7):795. doi:10.1001/jamaneurol.2020.0254

This article compares the author’s experience with mechanics who refused to believe that a car had a unique malfunction with her experience with clinicians who could not diagnose her rare disease.


Imaging Tau Pathology—The Next Step

Abstract Full Text
JAMA Neurol. 2020;77(7):796-797. doi:10.1001/jamaneurol.2020.0520

Longevity Gene KLOTHO and Alzheimer Disease—A Better Fate for Individuals Who Carry APOE ε4

Abstract Full Text
JAMA Neurol. 2020;77(7):798-800. doi:10.1001/jamaneurol.2020.0112
Original Investigation

Association Between Cardiovascular Disease and Long-term Exposure to Air Pollution With the Risk of Dementia

Abstract Full Text
open access
JAMA Neurol. 2020;77(7):801-809. doi:10.1001/jamaneurol.2019.4914

This cohort study investigates the association of long-term exposure to air pollution with dementia and evaluates the role of cardiovascular disease in the association among participants of the population-based Swedish National Study on Aging and Care in Kungsholmen.

Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals

Abstract Full Text
free access has active quiz
JAMA Neurol. 2020;77(7):810-819. doi:10.1001/jamaneurol.2020.0568

This cohort study assesses whether blood pressure levels are associated with racial differences in cognitive decline.

Evaluating the Risk of Macrovascular Events and Mortality Among People With Multiple Sclerosis in England

Abstract Full Text
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JAMA Neurol. 2020;77(7):820-828. doi:10.1001/jamaneurol.2020.0664

This cohort study assesses whether the risk of macrovascular events and mortality differs among people with multiple sclerosis compared with a matched population without multiple sclerosis in England.

Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes

Abstract Full Text
open access has active quiz
JAMA Neurol. 2020;77(7):829-839. doi:10.1001/jamaneurol.2020.0528

This diagnostic study explores whether positron emission tomography with [18F]flortaucipir can detect tau pathology and Alzheimer disease neuropathologic changes in terminally ill adults with or without dementia.

Effect of an Enhanced Paramedic Acute Stroke Treatment Assessment on Thrombolysis Delivery During Emergency Stroke Care: A Cluster Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2020;77(7):840-848. doi:10.1001/jamaneurol.2020.0611

This cluster randomized clinical trial sought to examine whether adding enhanced paramedic assessment to standard care would result in increased rates of thrombolysis in patients experiencing stroke.

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4

Abstract Full Text
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JAMA Neurol. 2020;77(7):849-862. doi:10.1001/jamaneurol.2020.0414

This study combined data from 35 independent case-control, family-based, and longitudinal cohorts that examined Alzheimer disease to determine if Klotho-VS heterozygosity is associated with reduced Alzheimer disease risk and β-amyloid (Aβ) pathology in individuals who carry APOE4.

Trends Among Rural and Urban Medicare Beneficiaries in Care Delivery and Outcomes for Acute Stroke and Transient Ischemic Attacks, 2008-2017

Abstract Full Text
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JAMA Neurol. 2020;77(7):863-871. doi:10.1001/jamaneurol.2020.0770

This cohort study describes trends among rural and urban patients with acute ischemic stroke or transient ischemic attack in the type of health care centers to which patients were admitted, what care was provided, and patient outcomes.

Brief Report

Association of Dermatomyositis Sine Dermatitis With Anti–Nuclear Matrix Protein 2 Autoantibodies

Abstract Full Text
JAMA Neurol. 2020;77(7):872-877. doi:10.1001/jamaneurol.2020.0673

This study confirms the existence of dermatomyositis sine dermatitis, determines its prevalence, and characterizes the serologic features of dermatomyositis sine dermatitis.

Special Communication

Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale–Associated Stroke

Abstract Full Text
JAMA Neurol. 2020;77(7):878-886. doi:10.1001/jamaneurol.2020.0458

This Special Communication describes new information on strokes associated with patent foramen ovale from randomized clinical trials and meta-analyses and proposes a new clinical approach to the categorization of such strokes.


Family History of Cluster Headache: A Systematic Review

Abstract Full Text
JAMA Neurol. 2020;77(7):887-896. doi:10.1001/jamaneurol.2020.0682

This systematic review uses articles published between 1985 and 2016 to examine family history rates and inheritance patterns of cluster headache.

Images in Neurology

Tumarkin Drop Attack Recorded by Video Surveillance

Abstract Full Text
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JAMA Neurol. 2020;77(7):897-898. doi:10.1001/jamaneurol.2020.0884

This case report describes a 47-year-old man with Meniere disease with recurrent vertigo that caused Tumarkin drop attacks.

Paraneoplastic Encephalomyelitis With Glutamic Acid Decarboxylase Antibodies Presenting as Longitudinal Pyramidal Tract Hyperintensity

Abstract Full Text
JAMA Neurol. 2020;77(7):899-900. doi:10.1001/jamaneurol.2020.0940

This case report describes a man with paraneoplastic neurological syndrome with paraneoplastic encephalomyelitis and small cell lung cancer who also had unusual pathophysiological features visible on magnetic resonance imaging.

Research Letter

Comparison of Placebos and Propensity Score Adjustment in Multiple Sclerosis Nonrandomized Studies

Abstract Full Text
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JAMA Neurol. 2020;77(7):902-903. doi:10.1001/jamaneurol.2020.0678

This comparative effectiveness research study examines propensity scores adjustment in multiple sclerosis studies comparing disease-modifying treatments.


Visualization of the Human Intracranial Vasa Vasorum In Vivo Using Optical Coherence Tomography

Abstract Full Text
JAMA Neurol. 2020;77(7):903-905. doi:10.1001/jamaneurol.2020.0546

This article provides in vivo images of the intracranial vasa vasorum taken by optical coherence tomography.

Comment & Response

Importance of the Intention-to-Treat Principle

Abstract Full Text
JAMA Neurol. 2020;77(7):905-906. doi:10.1001/jamaneurol.2020.0848

Importance of the Intention-to-Treat Principle—Reply

Abstract Full Text
JAMA Neurol. 2020;77(7):906-907. doi:10.1001/jamaneurol.2020.0866

Errors in Table 2

Abstract Full Text
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JAMA Neurol. 2020;77(7):907. doi:10.1001/jamaneurol.2020.1261
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2020;77(7):783. doi:10.1001/jamaneurol.2019.3209