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October 2023 - July 1959




October 2021, Vol 78, No. 10, Pages 1163-1278


Expanding Global Access to Neurology Education

Abstract Full Text
JAMA Neurol. 2021;78(10):1173-1174. doi:10.1001/jamaneurol.2021.2685

This Viewpoint discusses expanding global access to neurology education.

On the Brain

A Decision With Love

Abstract Full Text
JAMA Neurol. 2021;78(10):1175-1176. doi:10.1001/jamaneurol.2021.2758

This essay describes the decisions an emergency physician and a palliative care researcher was faced with after his father had an aneurysmal subarachnoid hemorrhage.


Building Inclusive and Open Alzheimer Disease and Alzheimer Disease–Related Dementias Research Programs

Abstract Full Text
JAMA Neurol. 2021;78(10):1177-1178. doi:10.1001/jamaneurol.2021.2941
Original Investigation

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial

Abstract Full Text
open access has active quiz
JAMA Neurol. 2021;78(10):1179-1186. doi:10.1001/jamaneurol.2021.2956

A follow-up of the Restart or Stop Antithrombotics Randomized Trial, this study further examines the long-term effects of antiplatelet therapy after stroke caused by intracerebral hemorrhage.

Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging

Abstract Full Text
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JAMA Neurol. 2021;78(10):1187-1196. doi:10.1001/jamaneurol.2021.2876

This cross-sectional study examines self-reported nighttime sleeping patterns, performance on cognition tests, and lifestyle and demographic variables in cognitively healthy older adults.

Treatment Escalation vs Immediate Initiation of Highly Effective Treatment for Patients With Relapsing-Remitting Multiple Sclerosis: Data From 2 Different National Strategies

Abstract Full Text
free access has active quiz
JAMA Neurol. 2021;78(10):1197-1204. doi:10.1001/jamaneurol.2021.2738

This cohort study uses data from Danish and Swedish national multiple sclerosis (MS) registries to investigate the association of national differences in disease-modifying treatment strategies for relapsing-remitting MS with disability outcomes.

Association of Tourette Syndrome and Chronic Tic Disorder With Cervical Spine Disorders and Related Neurological Complications

Abstract Full Text
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JAMA Neurol. 2021;78(10):1205-1211. doi:10.1001/jamaneurol.2021.2798

This cohort study assesses if Tourette syndrome or chronic tic disorder are associated with an increased risk of cervical spine disorders and related neurological complications compared with individuals from the general population.

General Anesthesia vs Local Anesthesia in Microelectrode Recording–Guided Deep-Brain Stimulation for Parkinson Disease: The GALAXY Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2021;78(10):1212-1219. doi:10.1001/jamaneurol.2021.2979

This randomized clinical trial compares deep brain stimulation surgery in the subthalamic nucleus for Parkinson disease under general anesthesia with surgery under local anesthesia.

Prehospital Comprehensive Stroke Center vs Primary Stroke Center Triage in Patients With Suspected Large Vessel Occlusion Stroke

Abstract Full Text
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JAMA Neurol. 2021;78(10):1220-1227. doi:10.1001/jamaneurol.2021.2485

This preimplementation-postimplementation study evaluates the association of a regional prehospital transport policy for comprehensive stroke center triage for patients with suspected acute ischemic stroke and large vessel occlusion with rates of endovascular therapy.

Risk of Rupture After Intracranial Aneurysm Growth

Abstract Full Text
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JAMA Neurol. 2021;78(10):1228-1235. doi:10.1001/jamaneurol.2021.2915

This cohort study evaluates the absolute risk of rupture of an aneurysm after detection of growth during follow-up and develops a prediction model for rupture.

Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis

Abstract Full Text
open access
JAMA Neurol. 2021;78(10):1236-1248. doi:10.1001/jamaneurol.2021.2598

This genetic association study identifies genetic variants associated with juvenile amyotrophic lateral sclerosis.

Brief Report

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

Abstract Full Text
open access
JAMA Neurol. 2021;78(10):1249-1254. doi:10.1001/jamaneurol.2021.2806

This cohort study determines whether the X chromosome is associated with sex-specific cognitive change and tau pathology in aging and Alzheimer disease.


Characterizing Demographic, Racial, and Geographic Diversity in Dementia Research: A Systematic Review

Abstract Full Text
JAMA Neurol. 2021;78(10):1255-1261. doi:10.1001/jamaneurol.2021.2943

This systematic review assesses the generalizability of research findings through contemporary dementia research in terms of study and patient characteristics.

Emerging Neuroimaging Biomarkers Across Disease Stage in Parkinson Disease: A Review

Abstract Full Text
JAMA Neurol. 2021;78(10):1262-1272. doi:10.1001/jamaneurol.2021.1312

This narrative review investigates the temporal relevance of diagnostic and progression imaging biomarkers to be used by clinicians and researchers over the clinical course of Parkinson disease.

JAMA Neurology Clinical Challenge

Facial Numbness, Dysarthria, Muscle Atrophy, and Weakness in a Young Patient

Abstract Full Text
has active quiz
JAMA Neurol. 2021;78(10):1273-1274. doi:10.1001/jamaneurol.2021.2136

A 19-year-old man presented with 4 years of facial numbness, 3 years of progressive dysarthria and dysphagia, 18 months of arm weakness and hand atrophy, and 6 months of leg weakness. On examination, dysarthria, bilateral peripheral facial paralysis, reduced facial touch and vibration sensitivity in the mandible, temporal muscle atrophy, and poor soft palate motility were observed. What is your diagnosis?

Research Letter

Computed Tomography vs Heavily T2-Weighted Magnetic Resonance Myelography for the Initial Evaluation of Patients With Spontaneous Intracranial Hypotension

Abstract Full Text
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JAMA Neurol. 2021;78(10):1275-1276. doi:10.1001/jamaneurol.2021.2868

This study compares the diagnostic accuracy of magnetic resonance myelography with computed tomography myelography for the identification of spinal cerebrospinal fluid leaks.

Comment & Response

Agent Orange Exposure and Dementia Diagnosis in US Veterans of the Vietnam Era

Abstract Full Text
JAMA Neurol. 2021;78(10):1276-1277. doi:10.1001/jamaneurol.2021.2606

Agent Orange Exposure and Dementia Diagnosis in US Veterans of the Vietnam Era—Reply

Abstract Full Text
JAMA Neurol. 2021;78(10):1277-1278. doi:10.1001/jamaneurol.2021.2609

Errors in Results and Table 1

Abstract Full Text
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JAMA Neurol. 2021;78(10):1278. doi:10.1001/jamaneurol.2021.2833

Error in Figure 2

Abstract Full Text
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JAMA Neurol. 2021;78(10):1278. doi:10.1001/jamaneurol.2021.2958
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2021;78(10):1163. doi:10.1001/jamaneurol.2020.3691