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December 4, 2023
Original Investigation

Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies

Abstract Full Text
JAMA Neurol. Published online December 4, 2023. doi:10.1001/jamaneurol.2023.4596

This cohort study analyzes data from participants with cognitive concerns to determine whether plasma biomarkers can identify amyloid β–positive individuals who do not yet have a high tau burden in the brain and would be suitable candidates for treatment with antiamyloid immunotherapies in Alzheimer disease.

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease

Abstract Full Text
open access
JAMA Neurol. Published online December 4, 2023. doi:10.1001/jamaneurol.2023.4398

This study investigate whether α-synuclein in neuronally derived serum-extracellular vesicles identifies individuals at risk of developing Parkinson disease and related dementia.

Images in Neurology

Mirror Hand Movements Caused by a Deletion of the DCC Gene

Abstract Full Text
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JAMA Neurol. Published online December 4, 2023. doi:10.1001/jamaneurol.2023.4563

This case report describes the evaluation of 16-year-old twins with chromosomal microarray and mirror movements.

Research Letter

Trends in Traumatic Brain Injury Mortality in the US

Abstract Full Text
JAMA Neurol. Published online December 4, 2023. doi:10.1001/jamaneurol.2023.4618

This cohort study characterizes US trends in traumatic brain injury–related mortality by age, sex, and race and ethnicity.

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