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Day

November 11, 2019
Original Investigation

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online November 11, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3812

This parallel-design, double-blind randomized clinical trial assesses the safety, tolerability, and pharmacodynamics of the microtubule stabilizer TPI-287 in patients with Alzheimer disease or the 4-repeat tauopathies progressive supranuclear palsy and corticobasal syndrome.

Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury

Abstract Full Text
open access
JAMA Neurol. Published online November 11, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3854

This single-center observational cohort study aims to comprehensively characterize the spatiotemporal changes in cerebral physiology after traumatic brain injury by comparing a cohort of affected patients with healthy control participants.

Images in Neurology

Developmental Venous Anomaly Inside a Glioblastoma

Abstract Full Text
has multimedia
JAMA Neurol. Published online November 11, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3840

This case report details an unusual developmental venous anomaly within a glioblastoma.

Comment & Response
Correction

Error in Text

Abstract Full Text
free access
JAMA Neurol. Published online November 11, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.4034
November 4, 2019
Viewpoint

Are Daylight Saving Time Changes Bad for the Brain?

Abstract Full Text
JAMA Neurol. Published online November 4, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3780

This Viewpoint reviews data associated with the US daylight saving time transition.

Editorial
Original Investigation

Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort

Abstract Full Text
open access
JAMA Neurol. Published online November 4, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3774

This longitudinal cohort study assesses the associations between vascular risk in early adulthood, midlife, and late life with late-life brain structure and β-amyloid load and white matter hyperintensity, whole-brain, and hippocampal volumes.

Images in Neurology

Distinctive Magnetic Resonance Imaging Findings in IgLON5 Antibody Disease

Abstract Full Text
JAMA Neurol. Published online November 4, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3638

This case report describes distinctive magnetic resonance imaging findings in a Chinese woman with IgLON5 antibody disease.

Correction

Error in Affiliation

Abstract Full Text
free access
JAMA Neurol. Published online November 4, 2019. doi:https://doi.org/10.1001/jamaneurol.2019.3877
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