This essay describes a visit to a library in the Institut du Cerveau et de la Moelle Épinière in Paris, France, that houses the works of Jean-Martin Charcot and several other scientists who contributed to early insights into neurology.
This randomized clinical trial tests the hypothesis that targeting intensive blood pressure lowering of systolic and diastolic blood pressure less than 120 mm Hg and less than 80 mm Hg, respectively, reduces the rate of stroke recurrence compared with a standard blood pressure–lowering regimen.
This prespecified secondary analysis of a cohort study compares outcomes in patients with large ischemic cores treated with endovascular thrombectomy vs medical management alone.
This cohort study assesses the feasibility of determining personalized blood pressure targets as well as the association of deviating from these targets with radiographic and clinical outcomes.
This Viewpoint presents insights into current research on rapid eye movement sleep behavior disorder, including offering tips on how to best proceed with future studies.
This population-based parent-offspring heritability study examines the extent of amyotrophic lateral sclerosis heritability and assesses the association of sex with disease transmission
This randomized clinical trial examines the effects, safety, and tolerability of AZD0530 medication in patients with mild Alzheimer disease.
This cohort assesses the clinical effectiveness of direct oral anticoagulants vs warfarin for stroke prevention in patients with atrial fibrillation.
This multicenter longitudinal cohort study of 741 participants uses in vivo β-amyloid cerebrospinal fluid and positron emission tomography findings to track progression of Alzheimer disease across 6 years of follow-up.
This study examines whether physical activity moderates the association of β-amyloid burden with longitudinal cognitive decline and neurodegeneration in clinically normal individuals.
This case-control study examines neuronal-enriched extracellular vesicles as predictors of Alzheimer disease.
This population-based cohort study estimates the sex- and age-specific prevalence of 3 imaging biomarker–based definitions of the Alzheimer disease spectrum from the National Institute on Aging–Alzheimer’s Association research framework and compares these entities with clinically defined diagnostic entities commonly linked with Alzheimer disease.
This study examines whether high body mass index in children and adolescents is a factor in the onset of multiple sclerosis and in treatment response.
This case report describes a 62-year-old man who presented with dizziness, right-sided numbness, and mild weakness for 10 days.
A 42-year-old man presents with a 2-month history of persistent muscle twitching in his abdomen and bilateral calves during wakefulness and sleep accompanied with excessive sweating, as well as mild bilateral lower extremity weakness after prolonged walking. What is your diagnosis?
This cohort study examines the association of lifespan cognitive reserve with dementia risk.
This essay describes a standard question from medical school interviews that first annoyed and then held special insight for the author.
This study analyzes the electronic medical records stored in The Health Improvement Network database of UK women with idiopathic intracranial hypertension to identify their cardiometabolic risks and outcomes.
This cohort study uses data from the Care Ecosystem study to investigate whether caregiver depression is associated with increased use of the emergency department among patients with dementia.
This phase 2 randomized clinical trial assesses the efficacy, safety, and tolerability of edonerpic maleate for patients with mild to moderate Alzheimer disease.
This Viewpoint discusses the management of idiopathic intracranial hypertension without papilledema in patients with chronic migraine.
This case-control study examines whether progressive cortical thinning in patients with focal epilepsy is distinct from cortical thinning associated with normal aging.
This cluster randomized clinical trial of stroke preparedness among black and Hispanic churchgoers evaluates the effect of culturally tailored 12-minute stroke films on stroke preparedness vs the usual care practice of distributing stroke education pamphlets.
This study compared Altmetric scores of neurological research as a marker of “buzz” with citations as a marker of academic attention.
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