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July 29, 2019
On the Brain

The Power of Observation in Neurology Then and Now—Notes From Charcot’s Library

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.1931

This essay describes a visit to a library in the Institut du Cerveau et de la Moelle Épinière in Paris, France, that houses the works of Jean-Martin Charcot and several other scientists who contributed to early insights into neurology.

Editorial

Challenges to Realizing Benefits From More Intensive Blood Pressure Control for Preventing Recurrent Stroke

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.1668

SELECTing Patients With Large Ischemic Core Who May Benefit From Endovascular Reperfusion

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.1789
Original Investigation

Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.2167

This randomized clinical trial tests the hypothesis that targeting intensive blood pressure lowering of systolic and diastolic blood pressure less than 120 mm Hg and less than 80 mm Hg, respectively, reduces the rate of stroke recurrence compared with a standard blood pressure–lowering regimen.

Outcomes of Endovascular Thrombectomy vs Medical Management Alone in Patients With Large Ischemic Cores: A Secondary Analysis of the Optimizing Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke (SELECT) Study

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.2109

This prespecified secondary analysis of a cohort study compares outcomes in patients with large ischemic cores treated with endovascular thrombectomy vs medical management alone.

Research Letter

Association of Personalized Blood Pressure Targets With Hemorrhagic Transformation and Functional Outcome After Endovascular Stroke Therapy

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.2120

This cohort study assesses the feasibility of determining personalized blood pressure targets as well as the association of deviating from these targets with radiographic and clinical outcomes.

July 22, 2019
Viewpoint

Factors Hampering the Discovery of New Therapeutics for Rapid Eye Movement Sleep Behavior Disorder

Abstract Full Text
JAMA Neurol. Published online July 22, 2019. doi:10.1001/jamaneurol.2019.2062

This Viewpoint presents insights into current research on rapid eye movement sleep behavior disorder, including offering tips on how to best proceed with future studies.

Original Investigation

Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. Published online July 22, 2019. doi:10.1001/jamaneurol.2019.2044

This population-based parent-offspring heritability study examines the extent of amyotrophic lateral sclerosis heritability and assesses the association of sex with disease transmission

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. Published online July 22, 2019. doi:10.1001/jamaneurol.2019.2050

This randomized clinical trial examines the effects, safety, and tolerability of AZD0530 medication in patients with mild Alzheimer disease.

Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study

Abstract Full Text
has audio
JAMA Neurol. Published online July 22, 2019. doi:10.1001/jamaneurol.2019.2099

This cohort assesses the clinical effectiveness of direct oral anticoagulants vs warfarin for stroke prevention in patients with atrial fibrillation.

July 17, 2019
Original Investigation

Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography

Abstract Full Text
JAMA Neurol. Published online July 17, 2019. doi:10.1001/jamaneurol.2019.2214

This multicenter longitudinal cohort study of 741 participants uses in vivo β-amyloid cerebrospinal fluid and positron emission tomography findings to track progression of Alzheimer disease across 6 years of follow-up.

July 16, 2019
Original Investigation

Associations of Physical Activity and β-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults

Abstract Full Text
JAMA Neurol. Published online July 16, 2019. doi:10.1001/jamaneurol.2019.1879

This study examines whether physical activity moderates the association of β-amyloid burden with longitudinal cognitive decline and neurodegeneration in clinically normal individuals.

July 15, 2019
Editorial

The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms

Abstract Full Text
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.1667
Original Investigation

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Abstract Full Text
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.2462

This case-control study examines neuronal-enriched extracellular vesicles as predictors of Alzheimer disease.

Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

Abstract Full Text
open access
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.1971

This population-based cohort study estimates the sex- and age-specific prevalence of 3 imaging biomarker–based definitions of the Alzheimer disease spectrum from the National Institute on Aging–Alzheimer’s Association research framework and compares these entities with clinically defined diagnostic entities commonly linked with Alzheimer disease.

Association of Obesity With Multiple Sclerosis Risk and Response to First-line Disease Modifying Drugs in Children

Abstract Full Text
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.1997

This study examines whether high body mass index in children and adolescents is a factor in the onset of multiple sclerosis and in treatment response.

Images in Neurology

Combined Cerebral Microbleeds With Lacunar Infarctions in Familial Cerebral Cavernous Malformations

Abstract Full Text
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.1980

This case report describes a 62-year-old man who presented with dizziness, right-sided numbness, and mild weakness for 10 days.

JAMA Neurology Clinical Challenge

A Case of Muscle Twitching With Psoriasis

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.1937

A 42-year-old man presents with a 2-month history of persistent muscle twitching in his abdomen and bilateral calves during wakefulness and sleep accompanied with excessive sweating, as well as mild bilateral lower extremity weakness after prolonged walking. What is your diagnosis?

Comment & Response

Dysregulation of the Reward and Learning Systems in Tourette Syndrome

Abstract Full Text
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.2027
July 14, 2019
Original Investigation

Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain Pathologies

Abstract Full Text
JAMA Neurol. Published online July 14, 2019. doi:10.1001/jamaneurol.2019.2455

This cohort study examines the association of lifespan cognitive reserve with dementia risk.

July 8, 2019
On the Brain

Why Do You Want To Be A Physician?

Abstract Full Text
JAMA Neurol. Published online July 8, 2019. doi:10.1001/jamaneurol.2019.1824

This essay describes a standard question from medical school interviews that first annoyed and then held special insight for the author.

Original Investigation

Association Between Idiopathic Intracranial Hypertension and Risk of Cardiovascular Diseases in Women in the United Kingdom

Abstract Full Text
open access
JAMA Neurol. Published online July 8, 2019. doi:10.1001/jamaneurol.2019.1812

This study analyzes the electronic medical records stored in The Health Improvement Network database of UK women with idiopathic intracranial hypertension to identify their cardiometabolic risks and outcomes.

Association Between Caregiver Depression and Emergency Department Use Among Patients With Dementia

Abstract Full Text
JAMA Neurol. Published online July 8, 2019. doi:10.1001/jamaneurol.2019.1820

This cohort study uses data from the Care Ecosystem study to investigate whether caregiver depression is associated with increased use of the emergency department among patients with dementia.

Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. Published online July 8, 2019. doi:10.1001/jamaneurol.2019.1868

This phase 2 randomized clinical trial assesses the efficacy, safety, and tolerability of edonerpic maleate for patients with mild to moderate Alzheimer disease.

July 1, 2019
Viewpoint

The Dilemma of Diagnosing Idiopathic Intracranial Hypertension Without Papilledema in Patients With Chronic Migraine

Abstract Full Text
JAMA Neurol. Published online July 1, 2019. doi:10.1001/jamaneurol.2019.1696

This Viewpoint discusses the management of idiopathic intracranial hypertension without papilledema in patients with chronic migraine.

Original Investigation

Progressive Cortical Thinning in Patients With Focal Epilepsy

Abstract Full Text
JAMA Neurol. Published online July 1, 2019. doi:10.1001/jamaneurol.2019.1708

This case-control study examines whether progressive cortical thinning in patients with focal epilepsy is distinct from cortical thinning associated with normal aging.

Effect of Stroke Education Pamphlets vs a 12-Minute Culturally Tailored Stroke Film on Stroke Preparedness Among Black and Hispanic Churchgoers: A Cluster Randomized Clinical Trial

Abstract Full Text
has multimedia
JAMA Neurol. Published online July 1, 2019. doi:10.1001/jamaneurol.2019.1741

This cluster randomized clinical trial of stroke preparedness among black and Hispanic churchgoers evaluates the effect of culturally tailored 12-minute stroke films on stroke preparedness vs the usual care practice of distributing stroke education pamphlets.

Research Letter

Comparison of Attention for Neurological Research on Social Media vs Academia: An Altmetric Score Analysis

Abstract Full Text
JAMA Neurol. Published online July 1, 2019. doi:10.1001/jamaneurol.2019.1791

This study compared Altmetric scores of neurological research as a marker of “buzz” with citations as a marker of academic attention.

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