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July 29, 2019

Challenges to Realizing Benefits From More Intensive Blood Pressure Control for Preventing Recurrent Stroke

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.1668
Original Investigation

Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis

Abstract Full Text
JAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.2167

This randomized clinical trial tests the hypothesis that targeting intensive blood pressure lowering of systolic and diastolic blood pressure less than 120 mm Hg and less than 80 mm Hg, respectively, reduces the rate of stroke recurrence compared with a standard blood pressure–lowering regimen.

July 22, 2019
Original Investigation

Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. Published online July 22, 2019. doi:10.1001/jamaneurol.2019.2044

This population-based parent-offspring heritability study examines the extent of amyotrophic lateral sclerosis heritability and assesses the association of sex with disease transmission

July 17, 2019
Original Investigation

Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography

Abstract Full Text
JAMA Neurol. Published online July 17, 2019. doi:10.1001/jamaneurol.2019.2214

This multicenter longitudinal cohort study of 741 participants uses in vivo β-amyloid cerebrospinal fluid and positron emission tomography findings to track progression of Alzheimer disease across 6 years of follow-up.

July 15, 2019
Original Investigation

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Abstract Full Text
JAMA Neurol. Published online July 15, 2019. doi:10.1001/jamaneurol.2019.2462

This case-control study examines neuronal-enriched extracellular vesicles as predictors of Alzheimer disease.

July 8, 2019
Original Investigation

Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. Published online July 8, 2019. doi:10.1001/jamaneurol.2019.1868

This phase 2 randomized clinical trial assesses the efficacy, safety, and tolerability of edonerpic maleate for patients with mild to moderate Alzheimer disease.