This Viewpoint discusses the author’s firsthand experience with clinical trials for patients with amyotrophic lateral sclerosis after her husband’s diagnosis.
This essay is about the author’s brother, who had severe intellectual disabilities, and his influence on her medical career.
This randomized clinical trial examines whether in-hospital treatment with remote ischemic perconditioning that is administered within 6 hours of symptom onset, with or without reperfusion therapy, can reduce brain infarction volume growth in patients with acute ischemic stroke.
This cohort study investigates the association of long-term exposure to air pollution with dementia and evaluates the role of cardiovascular disease in the association among participants of the population-based Swedish National Study on Aging and Care in Kungsholmen.
This cross-sectional study seeks to determine which brain changes, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism, are associated with the presence of sleep-disordered breathing in older individuals who are cognitively unimpaired.
This Special Communication discusses the formation of the National Institute of Neurological Disorders and Stroke Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) and what NeuroNEXT has accomplished within the first 7 years.
This review examines data from human and animal studies of the altered huntingtin protein associated with Huntington disease to assess the risk-benefit profile of huntingtin-lowering therapies for the treatment of people with Huntington disease.
This Viewpoint discusses how families interpret the discovery of covert consciousness in an unresponsive patient with brain injuries and how this might affect their clinical decisions, such as the withdrawal of care.
This article compares the author’s experience with mechanics who refused to believe that a car had a unique malfunction with her experience with clinicians who could not diagnose her rare disease.
This cohort study analyzes Swedish patient registries to identify the familial, lifestyle, cardiovascular, and other risk factors in the later development of neurodegenerative diseases among adults with stress-related disorders compared with their siblings and people without the condition.
This cohort study evaluates whether incident late-onset unprovoked seizures of unknown etiology are associated with a higher risk of developing dementia among older US veterans.
A 39-year-old woman presents with a 3-week history of worsening spasms in her axial and lower limb muscles, new-onset urinary retention, and sudden episodes of involuntary spasms in her abdominal muscles. What is your diagnosis?
This cross-sectional study examines paramagnetic rim sign positivity in patients with radiologically isolated syndrome.
This Viewpoint discusses the need for research on the environmental factors that influence amyotrophic lateral sclerosis.
This randomized clinical trial evaluates the efficacy and safety of 2 doses of a pharmaceutical formulation of cannabidiol vs placebo for adjunctive treatment of convulsive seizures in patients with Darvet syndrome.
This case report describes a girl with a right frontal leptomeningeal enhancement and a boy with a left hemispheric leptomeningeal enhancement.
Create a personal account or sign in to: