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Year

Day

March 30, 2020
Viewpoint

Improving Access to Clinical Trials for Amyotrophic Lateral Sclerosis Treatment

Abstract Full Text
JAMA Neurol. Published online March 30, 2020. doi:10.1001/jamaneurol.2020.0421

This Viewpoint discusses the author’s firsthand experience with clinical trials for patients with amyotrophic lateral sclerosis after her husband’s diagnosis.

On the Brain

A Future We Must Dare to Imagine

Abstract Full Text
JAMA Neurol. Published online March 30, 2020. doi:10.1001/jamaneurol.2020.0424

This essay is about the author’s brother, who had severe intellectual disabilities, and his influence on her medical career.

Original Investigation

Effect of In-Hospital Remote Ischemic Perconditioning on Brain Infarction Growth and Clinical Outcomes in Patients With Acute Ischemic Stroke: The RESCUE BRAIN Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online March 30, 2020. doi:10.1001/jamaneurol.2020.0326

This randomized clinical trial examines whether in-hospital treatment with remote ischemic perconditioning that is administered within 6 hours of symptom onset, with or without reperfusion therapy, can reduce brain infarction volume growth in patients with acute ischemic stroke.

Association Between Cardiovascular Disease and Long-term Exposure to Air Pollution With the Risk of Dementia

Abstract Full Text
open access
JAMA Neurol. Published online March 30, 2020. doi:10.1001/jamaneurol.2019.4914

This cohort study investigates the association of long-term exposure to air pollution with dementia and evaluates the role of cardiovascular disease in the association among participants of the population-based Swedish National Study on Aging and Care in Kungsholmen.

March 23, 2020
Editorial

JAMA Neurology—The Year in Review, 2019

Abstract Full Text
free access
JAMA Neurol. Published online March 23, 2020. doi:10.1001/jamaneurol.2020.0240
Original Investigation

Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online March 23, 2020. doi:10.1001/jamaneurol.2020.0311

This cross-sectional study seeks to determine which brain changes, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism, are associated with the presence of sleep-disordered breathing in older individuals who are cognitively unimpaired.

Special Communication

Seven-Year Experience From the National Institute of Neurological Disorders and Stroke–Supported Network for Excellence in Neuroscience Clinical Trials

Abstract Full Text
JAMA Neurol. Published online March 23, 2020. doi:10.1001/jamaneurol.2020.0367

This Special Communication discusses the formation of the National Institute of Neurological Disorders and Stroke Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT) and what NeuroNEXT has accomplished within the first 7 years.

Clinical Implications of Basic Neuroscience Research

Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks

Abstract Full Text
JAMA Neurol. Published online March 23, 2020. doi:10.1001/jamaneurol.2020.0299

This review examines data from human and animal studies of the altered huntingtin protein associated with Huntington disease to assess the risk-benefit profile of huntingtin-lowering therapies for the treatment of people with Huntington disease.

Peer Reviewers List

JAMA Neurology Peer Reviewers in 2019

Abstract Full Text
free access
JAMA Neurol. Published online March 23, 2020. doi:10.1001/jamaneurol.2020.0110
March 16, 2020
Viewpoint

Translating the Discovery of Covert Consciousness Into Clinical Practice

Abstract Full Text
JAMA Neurol. Published online March 16, 2020. doi:10.1001/jamaneurol.2020.0232

This Viewpoint discusses how families interpret the discovery of covert consciousness in an unresponsive patient with brain injuries and how this might affect their clinical decisions, such as the withdrawal of care.

On the Brain

Check Engine Light

Abstract Full Text
JAMA Neurol. Published online March 16, 2020. doi:10.1001/jamaneurol.2020.0254

This article compares the author’s experience with mechanics who refused to believe that a car had a unique malfunction with her experience with clinicians who could not diagnose her rare disease.

March 9, 2020
Original Investigation

Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases

Abstract Full Text
JAMA Neurol. Published online March 9, 2020. doi:10.1001/jamaneurol.2020.0117

This cohort study analyzes Swedish patient registries to identify the familial, lifestyle, cardiovascular, and other risk factors in the later development of neurodegenerative diseases among adults with stress-related disorders compared with their siblings and people without the condition.

Association of Late-Onset Unprovoked Seizures of Unknown Etiology With the Risk of Developing Dementia in Older Veterans

Abstract Full Text
JAMA Neurol. Published online March 9, 2020. doi:10.1001/jamaneurol.2020.0187

This cohort study evaluates whether incident late-onset unprovoked seizures of unknown etiology are associated with a higher risk of developing dementia among older US veterans.

JAMA Neurology Clinical Challenge

Spasms and Myoclonus in a Young Woman With Hashimoto Thyroiditis

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. Published online March 9, 2020. doi:10.1001/jamaneurol.2020.0175

A 39-year-old woman presents with a 3-week history of worsening spasms in her axial and lower limb muscles, new-onset urinary retention, and sudden episodes of involuntary spasms in her abdominal muscles. What is your diagnosis?

Research Letter

Paramagnetic Rim Sign in Radiologically Isolated Syndrome

Abstract Full Text
JAMA Neurol. Published online March 9, 2020. doi:10.1001/jamaneurol.2020.0124

This cross-sectional study examines paramagnetic rim sign positivity in patients with radiologically isolated syndrome.

March 2, 2020
Viewpoint

Voicing the Need for Amyotrophic Lateral Sclerosis Environmental Research

Abstract Full Text
JAMA Neurol. Published online March 2, 2020. doi:10.1001/jamaneurol.2020.0051

This Viewpoint discusses the need for research on the environmental factors that influence amyotrophic lateral sclerosis.

Original Investigation

Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. Published online March 2, 2020. doi:10.1001/jamaneurol.2020.0073

This randomized clinical trial evaluates the efficacy and safety of 2 doses of a pharmaceutical formulation of cannabidiol vs placebo for adjunctive treatment of convulsive seizures in patients with Darvet syndrome.

Images in Neurology

Unilateral Leptomeningeal Enhancement in Myelin Oligodendrocyte Glycoprotein Immunoglobulin G–Associated Disease

Abstract Full Text
JAMA Neurol. Published online March 2, 2020. doi:10.1001/jamaneurol.2020.0001

This case report describes a girl with a right frontal leptomeningeal enhancement and a boy with a left hemispheric leptomeningeal enhancement.

Comment & Response

We Dropped the Reflex Hammer on Hypertension 20 Years Ago

Abstract Full Text
JAMA Neurol. Published online March 2, 2020. doi:10.1001/jamaneurol.2020.0070

We Dropped the Reflex Hammer on Hypertension 20 Years Ago—Reply

Abstract Full Text
JAMA Neurol. Published online March 2, 2020. doi:10.1001/jamaneurol.2020.0083
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