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Day

April 27, 2020
Viewpoint

White Matter Degeneration—A Treatable Target?

Abstract Full Text
JAMA Neurol. Published online April 27, 2020. doi:10.1001/jamaneurol.2020.0814

This Viewpoint discusses white matter degeneration as a potentially treatable target for reducing cognitive impairment and dementia.

On the Brain

Mostly Able

Abstract Full Text
JAMA Neurol. Published online April 27, 2020. doi:10.1001/jamaneurol.2020.0776

This essay discusses the experience of physicians with neurological disabilities navigating their work and careers.

Editorial

Imaging Tau Pathology—The Next Step

Abstract Full Text
JAMA Neurol. Published online April 27, 2020. doi:10.1001/jamaneurol.2020.0520
Original Investigation

Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes

Abstract Full Text
open access
JAMA Neurol. Published online April 27, 2020. doi:10.1001/jamaneurol.2020.0528

This diagnostic study explores whether positron emission tomography with [18F]flortaucipir can detect tau pathology and Alzheimer disease neuropathologic changes in terminally ill adults with or without dementia.

Factors Contributing to Major Neurological Complications From Vein of Galen Malformation Embolization

Abstract Full Text
JAMA Neurol. Published online April 27, 2020. doi:10.1001/jamaneurol.2020.0825

This cohort study assesses the rate of major periprocedural neurological complications in Canadian children following vein of Galen malformation embolization with major procedural and strategic contributors.

Review

Monitoring Clinical Course and Treatment Response in Chronic Inflammatory Demyelinating Polyneuropathy During Routine Care: A Review of Clinical and Laboratory Assessment Measures

Abstract Full Text
JAMA Neurol. Published online April 27, 2020. doi:10.1001/jamaneurol.2020.0781

This narrative review provides an overview of specific outcomes that are appropriate for chronic inflammatory demyelinating polyneuropathy monitoring during routine clinical care and highlights the minimum clinically important difference, if known.

April 24, 2020
Viewpoint

The Coronavirus Disease 2019 Crisis as Catalyst for Telemedicine for Chronic Neurological Disorders

Abstract Full Text
free access has active quiz
JAMA Neurol. Published online April 24, 2020. doi:10.1001/jamaneurol.2020.1452

This Viewpoint describes the reasons for and reality of a rapid advance towards telemedicine in neurology during the coronavirus disease 2019 pandemic.

April 20, 2020
Original Investigation

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study

Abstract Full Text
JAMA Neurol. Published online April 20, 2020. doi:10.1001/jamaneurol.2020.0428

This genetic association study compares gene loci for Parkinson Disease in cohorts of Asian and European individuals with Parkinson disease.

Brief Report

Association of Dermatomyositis Sine Dermatitis With Anti–Nuclear Matrix Protein 2 Autoantibodies

Abstract Full Text
JAMA Neurol. Published online April 20, 2020. doi:10.1001/jamaneurol.2020.0673

This study confirms the existence of dermatomyositis sine dermatitis, determines its prevalence, and characterizes the serologic features of dermatomyositis sine dermatitis.

Review

Family History of Cluster Headache: A Systematic Review

Abstract Full Text
JAMA Neurol. Published online April 20, 2020. doi:10.1001/jamaneurol.2020.0682

This systematic review uses articles published between 1985 and 2016 to examine family history rates and inheritance patterns of cluster headache.

Research Letter

Comparison of Placebos and Propensity Score Adjustment in Multiple Sclerosis Nonrandomized Studies

Abstract Full Text
JAMA Neurol. Published online April 20, 2020. doi:10.1001/jamaneurol.2020.0678

This comparative effectiveness research study examines propensity scores adjustment in multiple sclerosis studies comparing disease-modifying treatments.

Comment & Response

Magnetic Resonance Imaging for Acute Minor Neurological Symptoms: Good for Ruling Stroke in, Not Out

Abstract Full Text
JAMA Neurol. Published online April 20, 2020. doi:10.1001/jamaneurol.2020.0661
April 13, 2020
Editorial

Longevity Gene KLOTHO and Alzheimer Disease—A Better Fate for Individuals Who Carry APOE ε4

Abstract Full Text
JAMA Neurol. Published online April 13, 2020. doi:10.1001/jamaneurol.2020.0112
Original Investigation

Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals

Abstract Full Text
JAMA Neurol. Published online April 13, 2020. doi:10.1001/jamaneurol.2020.0568

This cohort study assesses whether blood pressure levels are associated with racial differences in cognitive decline.

Effect of an Enhanced Paramedic Acute Stroke Treatment Assessment on Thrombolysis Delivery During Emergency Stroke Care: A Cluster Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. Published online April 13, 2020. doi:10.1001/jamaneurol.2020.0611

This cluster randomized clinical trial sought to examine whether adding enhanced paramedic assessment to standard care would result in increased rates of thrombolysis in patients experiencing stroke.

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4

Abstract Full Text
JAMA Neurol. Published online April 13, 2020. doi:10.1001/jamaneurol.2020.0414

This study combined data from 35 independent case-control, family-based, and longitudinal cohorts that examined Alzheimer disease to determine if Klotho-VS heterozygosity is associated with reduced Alzheimer disease risk and β-amyloid (Aβ) pathology in individuals who carry APOE4.

Special Communication

Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale–Associated Stroke

Abstract Full Text
JAMA Neurol. Published online April 13, 2020. doi:10.1001/jamaneurol.2020.0458

This Special Communication describes new information on strokes associated with patent foramen ovale from randomized clinical trials and meta-analyses and proposes a new clinical approach to the categorization of such strokes.

Observation

Visualization of the Human Intracranial Vasa Vasorum In Vivo Using Optical Coherence Tomography

Abstract Full Text
JAMA Neurol. Published online April 13, 2020. doi:10.1001/jamaneurol.2020.0546

This article provides in vivo images of the intracranial vasa vasorum taken optical coherence tomography.

April 10, 2020
Editorial

The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines

Abstract Full Text
free access has active quiz
JAMA Neurol. Published online April 10, 2020. doi:10.1001/jamaneurol.2020.1065
Original Investigation

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Abstract Full Text
free access has active quiz
JAMA Neurol. Published online April 10, 2020. doi:10.1001/jamaneurol.2020.1127

This study investigates the neurologic manifestations of patients with coronavirus disease 2019.

April 6, 2020
Viewpoint

Deprescribing in Epilepsy: Do No Harm

Abstract Full Text
JAMA Neurol. Published online April 6, 2020. doi:10.1001/jamaneurol.2020.0473

This Viewpoint discusses the emerging field of deprescribing and how to advance deprescribing among patients with epilepsy.

Editorial

Triage Based on Preclinical Scores—Low-Cost Strategy for Accelerating Time to Thrombectomy

Abstract Full Text
JAMA Neurol. Published online April 6, 2020. doi:10.1001/jamaneurol.2020.0113
Original Investigation

Implementation of a Prehospital Stroke Triage System Using Symptom Severity and Teleconsultation in the Stockholm Stroke Triage Study

Abstract Full Text
JAMA Neurol. Published online April 6, 2020. doi:10.1001/jamaneurol.2020.0319

This cohort study examines a system for prehospital triage for Swedish patients with suspected acute stroke.

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals

Abstract Full Text
has audio
JAMA Neurol. Published online April 6, 2020. doi:10.1001/jamaneurol.2020.0387

This cross-sectional analysis examines the association of elevated amyloid with demographic and lifestyle factors, apolipoprotein E, neuropsychological testing, and self- and study partner reports of cognitive function among participants in the A4 Study.

Comment & Response

Uncertain Association Between Concussion and Hypogonadism

Abstract Full Text
JAMA Neurol. Published online April 6, 2020. doi:10.1001/jamaneurol.2020.0470

Uncertain Association Between Concussion and Hypogonadism—Reply

Abstract Full Text
JAMA Neurol. Published online April 6, 2020. doi:10.1001/jamaneurol.2020.0476
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