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Year

Day

June 29, 2020
Viewpoint

Rethinking Regional Neurologic Care in the Coronavirus Disease 2019 Era

Abstract Full Text
free access
JAMA Neurol. Published online June 29, 2020. doi:10.1001/jamaneurol.2020.1956

This Viewpoint discusses ways to reduce overtriage for patients with neurologic disease and finding ways to care for patients at a distance during the coronavirus disease 2019 pandemic.

Editorial

Modifiable Lifestyle Factors in Alzheimer Disease: An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration

Abstract Full Text
JAMA Neurol. Published online June 29, 2020. doi:10.1001/jamaneurol.2020.1114
Original Investigation

Association of Early-Life Cognitive Enrichment With Alzheimer Disease Pathological Changes and Cognitive Decline

Abstract Full Text
JAMA Neurol. Published online June 29, 2020. doi:10.1001/jamaneurol.2020.1941

This cohort study examines the association of early-life cognitive enrichment with late-life Alzheimer disease and other common dementia-related pathological changes in an autopsy sample.

Comment & Response

Dopamine Metabolite Biomarkers and Testing for Disease Modification in Parkinson Disease

Abstract Full Text
JAMA Neurol. Published online June 29, 2020. doi:10.1001/jamaneurol.2020.1928

Dopamine Metabolite Biomarkers and Testing for Disease Modification in Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. Published online June 29, 2020. doi:10.1001/jamaneurol.2020.1931
June 26, 2020
Original Investigation

Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis

Abstract Full Text
free access
JAMA Neurol. Published online June 26, 2020. doi:10.1001/jamaneurol.2020.2581

This cohort study describes the clinical characteristics and outcomes in patients with multiple sclerosis who contract COVID-19 and identifies factors associated with COVID-19 severity.

June 22, 2020
Original Investigation

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults

Abstract Full Text
JAMA Neurol. Published online June 22, 2020. doi:10.1001/jamaneurol.2020.1741

This cohort study examines brain autopsy data for the presence of quadruple misfolded proteins (tau, amyloid-β, α-synuclein, and transactive response DNA-binding protein 43) and their association with cognitive decline in older adults.

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease

Abstract Full Text
JAMA Neurol. Published online June 22, 2020. doi:10.1001/jamaneurol.2020.1760

This genetic association study examines amyloid levels through positron emission tomographic imaging in individuals with or at risk for Alzheimer disease.

Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy–Related Inflammation

Abstract Full Text
JAMA Neurol. Published online June 22, 2020. doi:10.1001/jamaneurol.2020.1782

This cohort study examines the clinical, neuroimaging, laboratory, pathologic, or treatment-related associations with outcomes after an episode of cerebral amyloid angiopathy-related inflammation.

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial

Abstract Full Text
has audio
JAMA Neurol. Published online June 22, 2020. doi:10.1001/jamaneurol.2020.1840

This randomized clinical trial examines the safety, efficacy, and feasibility of intranasal insulin for the treatment of persons with mild cognitive impairment and Alzheimer disease dementia.

Images in Neurology

Spinal Cord Infarction and Metastasis Attributable to Atrial Myxoma

Abstract Full Text
JAMA Neurol. Published online June 22, 2020. doi:10.1001/jamaneurol.2020.1495

This case report describes spinal cord infarction in a middle-aged man diagnosed with cardiac myxoma.

Research Letter

Changing Causes of US Neurological Disease Mortality From 1999 to 2017

Abstract Full Text
JAMA Neurol. Published online June 22, 2020. doi:10.1001/jamaneurol.2020.1878

This study estimates neurological disease mortality rate trends in the US population from 1999 to 2017 as well as regionalized differences within the US.

June 15, 2020
Viewpoint

Addressing Health Disparities Among Minority Populations: Why Clinical Trial Recruitment Is Not Enough

Abstract Full Text
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.1614

This Viewpoint discusses health care disparities among racial/ethnic minority populations, focusing on recruitment to clinical trials for Alzheimer disease.

Editorial

Keep the Worms in the Mud

Abstract Full Text
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.0519
Original Investigation

Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial

Abstract Full Text
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.1118

This randomized clinical trial assesses the effect of hookworm treatment on magnetic resonance imaging activity and T regulatory cells in British patients with relapsing multiple sclerosis.

Association of Circadian Abnormalities in Older Adults With an Increased Risk of Developing Parkinson Disease

Abstract Full Text
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.1623

This cohort study assesses the association between rest-activity rhythm and risk of incident Parkinson disease and explores whether this association is independent of nighttime sleep disturbances in community-dwelling older men.

Analysis of Normal High-Frequency Intracranial Pressure Values and Treatment Threshold in Neurocritical Care Patients: Insights into Normal Values and a Potential Treatment Threshold

Abstract Full Text
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.1310

This study investigates associations between intracranial pressure values and outcomes in neurocritical care patients.

Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial

Abstract Full Text
open access
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.1484

This nonrandomized controlled trial analyzes safety, biological, and functional outcomes associated with the infusion of rAAVrh74.MHCK7.micro-dystrophin gene transfer in a small group of patients with Duchenne muscular dystrophy.

JAMA Neurology Clinical Challenge

Encephalomyelitis and Lymphadenopathy in a Man in His Early 40s

Abstract Full Text
has active quiz
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.1634

A 43-year-old man presents with spinal cord syndrome and generalized lymphadenopathy. Multiple enhancing lesions were detected both in brain and cervical cord. What is your diagnosis?

Correction

Error in Figure Caption

Abstract Full Text
free access
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.1973

Error in Figure

Abstract Full Text
free access
JAMA Neurol. Published online June 15, 2020. doi:10.1001/jamaneurol.2020.2025
June 8, 2020
Viewpoint

Preventing an Acute Flaccid Myelitis Epidemic in the Time of a Pandemic

Abstract Full Text
JAMA Neurol. Published online June 8, 2020. doi:10.1001/jamaneurol.2020.1545

This Viewpoint discusses the importance of developing vaccines even after an epidemic ends because it may help with vaccine development for a future viruses in the same family.

Original Investigation

Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016

Abstract Full Text
JAMA Neurol. Published online June 8, 2020. doi:10.1001/jamaneurol.2020.1512

This cohort study examines data from original and offspring participants in the Framingham Heart Study to assess the incidence of intracerebral hemorrhage, incidence rates stratified by deep and lobar brain locations, and location-specific risk factors between 1948 and 2016.

Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials

Abstract Full Text
open access
JAMA Neurol. Published online June 8, 2020. doi:10.1001/jamaneurol.2020.1568

This secondary analysis of data from 2 randomized clinical trials examines the relative contribution of relapse-associated vs relapse-independent progression to overall confirmed disability accumulation in patients with multiple sclerosis and assesses respective baseline prognostic factors and outcomes of the 2 treatments.

Correction

Correction to Author’s Academic Degrees

Abstract Full Text
free access
JAMA Neurol. Published online June 8, 2020. doi:10.1001/jamaneurol.2020.1700
June 1, 2020
On the Brain

Any Recent Stressors?—A Memoir of Transient Global Amnesia

Abstract Full Text
JAMA Neurol. Published online June 1, 2020. doi:10.1001/jamaneurol.2020.1403

This essay describes the author’s experience with transient global amnesia and the treatment he received as a patient.

Original Investigation

Evaluation of a New Criterion for Detecting Prion Disease With Diffusion Magnetic Resonance Imaging

Abstract Full Text
JAMA Neurol. Published online June 1, 2020. doi:10.1001/jamaneurol.2020.1319

This diagnostic study assesses the sensitivity and specificity of diffusion magnetic resonance imaging with a new criterion of at least 1 positive brain region for the diagnosis of sporadic Creutzfeldt-Jakob disease.

Comparative Effectiveness of Carotid Endarterectomy vs Initial Medical Therapy in Patients With Asymptomatic Carotid Stenosis

Abstract Full Text
open access
JAMA Neurol. Published online June 1, 2020. doi:10.1001/jamaneurol.2020.1427

This comparative effectiveness study describes the analytical strategy, methods, and results of a target trial emulation examining cohorts of US veterans with carotid stenosis.

Research Letter

Migraines During Pregnancy and the Risk of Maternal Stroke

Abstract Full Text
JAMA Neurol. Published online June 1, 2020. doi:10.1001/jamaneurol.2020.1435

This cohort study examines the extent to which hypertensive disorders mediate the association between migraines and maternal stroke.

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