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Year

Day

July 27, 2020
Viewpoint

Time for a New Image of Parkinson Disease

Abstract Full Text
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.2412

This Viewpoint discusses an updated image of Parkinson disease that more accurately reflects the heterogeneity in age at onset, sex, race/ethnicity, and disease experience.

Editorial

Continuous Electroencephalogram—Necessity or Luxury?

Abstract Full Text
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.1483
Original Investigation

Continuous vs Routine Electroencephalogram in Critically Ill Adults With Altered Consciousness and No Recent Seizure: A Multicenter Randomized Clinical Trial

Abstract Full Text
open access has audio
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.2264

This randomized clinical trial investigates whether continuous electroencephalogram is associated with reduced mortality compared with routine electroencephalogram.

Association of Sustained Immunotherapy With Disability Outcomes in Patients With Active Secondary Progressive Multiple Sclerosis

Abstract Full Text
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.2453

This cohort study uses data from the MSBase international registry to examine the association of demographic and clinical factors, including the presence of relapses and exposure to immunotherapy, with the rate of disability accumulation in patients with secondary progressive multiple sclerosis.

Trends in Antihypertensive Medication Use Among Individuals With a History of Stroke and Hypertension, 2005 to 2016

Abstract Full Text
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.2499

This cross-sectional study investigates the adequacy of blood pressure control among stroke survivors and antihypertensive treatment trends using National Health and Nutrition Examination Survey data.

Review

New Horizons in Pharmacologic Therapy for Secondary Stroke Prevention

Abstract Full Text
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.2494

This narrative review summarizes the results of recent and ongoing randomized clinical trials of drugs for secondary stroke prevention.

Images in Neurology

Longitudinally Extensive Spinal Cord Lesion in Erdheim-Chester Disease

Abstract Full Text
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.2460

This case report describes a 67-year-old man with 4 years of progressive quadriparesis and dysarthria, progressive right more than left lower limb weakness, and difficulty walking.

Correction

Mislabeled Curves in a Figure

Abstract Full Text
free access
JAMA Neurol. Published online July 27, 2020. doi:10.1001/jamaneurol.2020.2784
July 20, 2020
Viewpoint

Stroke Thrombolysis With Tenecteplase to Reduce Emergency Department Spread of Coronavirus Disease 2019 and Shortages of Alteplase

Abstract Full Text
has active quiz
JAMA Neurol. Published online July 20, 2020. doi:10.1001/jamaneurol.2020.2396

This Viewpoint advocates for expanded usage of tenecteplase in patients with stroke as a means of avoiding coronavirus disease 2019 spread and easing potential shortages of alteplase.

Original Investigation

Hypoxic-Ischemic Encephalopathy Evaluated by Brain Autopsy and Neuroprognostication After Cardiac Arrest

Abstract Full Text
JAMA Neurol. Published online July 20, 2020. doi:10.1001/jamaneurol.2020.2340

This cohort study compares the parameters used for prognosis after cardiac arrest with the severity of hypoxic-ischemic encephalopathy shown on autopsy.

A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. Published online July 20, 2020. doi:10.1001/jamaneurol.2020.2349

This meta-analysis evaluates which factors are associated with diffusion-weighted imaging lesions and whether these lesions are associated with functional outcomes among patients with intracerebral hemorrhage.

Images in Neurology

Spontaneous Intracranial Hypotension With Brain Sagging Attributable to a Cerebrospinal Fluid–Venous Fistula

Abstract Full Text
JAMA Neurol. Published online July 20, 2020. doi:10.1001/jamaneurol.2020.2372

This case report describes a 44-year-old man who presented with positional headaches and other symptoms and was found to have spontaneous intracranial hypotension because of a cerebrospinal fluid–venous fistula.

Correction

Error in Author Names and Figure Labels

Abstract Full Text
free access
JAMA Neurol. Published online July 20, 2020. doi:10.1001/jamaneurol.2020.2579
July 13, 2020
Original Investigation

Association of Delirium With Long-term Cognitive Decline: A Meta-analysis

Abstract Full Text
JAMA Neurol. Published online July 13, 2020. doi:10.1001/jamaneurol.2020.2273

This meta-analysis seeks to determine if an episode of delirium is an independent risk factor for long-term cognitive decline.

Images in Neurology

Spinal Cord Involvement in Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

Abstract Full Text
JAMA Neurol. Published online July 13, 2020. doi:10.1001/jamaneurol.2020.2204

This case report describes novel magnetic resonance imaging findings in a man with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.

Correction

Error in the Biomarker Subsection

Abstract Full Text
free access
JAMA Neurol. Published online July 13, 2020. doi:10.1001/jamaneurol.2020.2416
July 7, 2020
Original Investigation

Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy

Abstract Full Text
open access
JAMA Neurol. Published online July 7, 2020. doi:10.1001/jamaneurol.2020.2526

This cross-sectional study investigates the potential of novel tau radiotracer 18F-PI-2620 as a biomarker in patients with clinically diagnosed progressive supranuclear palsy.

July 6, 2020
Editorial

Should Neurologists Be Concerned With REM Sleep Quantity?

Abstract Full Text
JAMA Neurol. Published online July 6, 2020. doi:10.1001/jamaneurol.2020.2122
Original Investigation

Association of Rapid Eye Movement Sleep With Mortality in Middle-aged and Older Adults

Abstract Full Text
JAMA Neurol. Published online July 6, 2020. doi:10.1001/jamaneurol.2020.2108

This cross-sectional study investigates whether rapid eye movement sleep is associated with greater risk of mortality in 2 independent cohorts and explores whether another sleep stage could be driving these findings.

Characteristics of Recurrent Ischemic Stroke After Embolic Stroke of Undetermined Source: Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online July 6, 2020. doi:10.1001/jamaneurol.2020.1995

This secondary analysis of a randomized clinical trial assesses the subtype of recurrent ischemic stroke after embolic stroke of underdetermined source, the interaction with treatment assignment, and the consistency of cerebral location of the qualifying and recurrent strokes in the study population of the NAVIGATE-ESUS trial.

Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials: A Population-Based Study and Systematic Review

Abstract Full Text
open access
JAMA Neurol. Published online July 6, 2020. doi:10.1001/jamaneurol.2020.1948

This systematic review and meta-analysis examines the recurrence of ischemic stroke and possible use of patent foramen ovale closure in patients aged 60 years or older.

Images in Neurology

Tattoo Reaction—a Diagnostic Clue in Neurosarcoidosis

Abstract Full Text
JAMA Neurol. Published online July 6, 2020. doi:10.1001/jamaneurol.2020.2017

This case report details a man who experienced neurosarcoidosis for which an early diagnostic clue was a skin reaction to a tattoo.

July 2, 2020
Original Investigation

Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza

Abstract Full Text
free access has active quiz
JAMA Neurol. Published online July 2, 2020. doi:10.1001/jamaneurol.2020.2730

This cohort study compares the rate of ischemic stroke among patients with COVID-19 vs patients with influenza in 2 hospitals in New York City, New York.

July 1, 2020
Brief Report

Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children

Abstract Full Text
free access
JAMA Neurol. Published online July 1, 2020. doi:10.1001/jamaneurol.2020.2687

This case series presents the clinical findings of 4 children who experienced neurological manifestations of coronavirus disease 2019.

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