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July 26, 2021
Viewpoint

Neurocysticercosis as an Eradicable Cause of Epilepsy: A Plan and Actions Are Needed

Abstract Full Text
JAMA Neurol. Published online July 26, 2021. doi:10.1001/jamaneurol.2021.2349

This Viewpoint describes efforts to eradicate neurocysticercosis, a disease that causes nearly one-third of all epilepsy cases in low-income settings.

Editorial

Selection of Patients for Thrombectomy in the Extended Time Window

Abstract Full Text
JAMA Neurol. Published online July 26, 2021. doi:10.1001/jamaneurol.2021.1825
Original Investigation

Assessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database

Abstract Full Text
JAMA Neurol. Published online July 26, 2021. doi:10.1001/jamaneurol.2021.2319

This pooled analysis uses data from 6 randomized clinical trials to assess the potential benefits of endovascular thrombectomy among patients with ischemic stroke based on 3 baseline imaging profiles.

Seizure Prophylaxis After Spontaneous Intracerebral Hemorrhage

Abstract Full Text
has audio
JAMA Neurol. Published online July 26, 2021. doi:10.1001/jamaneurol.2021.2249

This decision analytic study uses a simulation model to evaluate the trade-offs associated with 4 treatment strategies based on primary vs secondary prophylactic therapy, timing of seizures, and duration of therapy in patients with spontaneous intracerebral hemorrhage.

Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

Abstract Full Text
JAMA Neurol. Published online July 26, 2021. doi:10.1001/jamaneurol.2021.2293

This cross-sectional study compares amyloid and tau positron emission tomography measures, neurodegeneration, vascular pathology, and cognitive outcomes using plasma p-tau181 and p-tau231 on the single-molecule array platform vs p-tau181 and p-tau217 on the Meso Scale Discovery platform among participants without dementia enrolled in the Mayo Clinic Study on Aging.

July 19, 2021
Editorial

Young-Onset Dementia—New Insights for an Underappreciated Problem

Abstract Full Text
JAMA Neurol. Published online July 19, 2021. doi:10.1001/jamaneurol.2021.1760
Original Investigation

Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. Published online July 19, 2021. doi:10.1001/jamaneurol.2021.2161

This systematic review and meta-analysis assesses the global prevalence of young-onset dementia.

Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI

Abstract Full Text
open access
JAMA Neurol. Published online July 19, 2021. doi:10.1001/jamaneurol.2021.2120

The longitudinal, observational study aims to identify pathological computed tomography features associated with adverse outcomes after mild traumatic brain injury.

JAMA Neurology Clinical Challenge

Multiple Facial Ulcers Following a Stroke

Abstract Full Text
has active quiz
JAMA Neurol. Published online July 19, 2021. doi:10.1001/jamaneurol.2021.2236

A 66-year-old man presents with multiple progressive ulcers and hypesthesia on the right side of his face, new-onset hemiplegia and hemianopsia on the left side of his face, and ischemic posterior circulation stroke. What is your diagnosis?

July 12, 2021
Images in Neurology

Mirrored-Self Misidentification in a Patient With Probable Alzheimer Dementia

Abstract Full Text
free access has multimedia
JAMA Neurol. Published online July 12, 2021. doi:10.1001/jamaneurol.2021.2142

This case report describes a 77-year-old man with probable Alzheimer dementia who was unable to recognize his reflection in a mirror.

JAMA Neurology Clinical Challenge

Facial Numbness, Dysarthria, Muscle Atrophy, and Weakness in a Young Patient

Abstract Full Text
has active quiz
JAMA Neurol. Published online July 12, 2021. doi:10.1001/jamaneurol.2021.2136

A 19-year-old man presented with 4 years of facial numbness, 3 years of progressive dysarthria and dysphagia, 18 months of arm weakness and hand atrophy, and 6 months of leg weakness. On examination, dysarthria, bilateral peripheral facial paralysis, reduced facial touch and vibration sensitivity in the mandible, temporal muscle atrophy, and poor soft palate motility were observed. What is your diagnosis?

Correction

Addition of Video Titles

Abstract Full Text
free access
JAMA Neurol. Published online July 12, 2021. doi:10.1001/jamaneurol.2021.2329
July 9, 2021
Original Investigation

Efficacy and Safety of Ticagrelor and Aspirin in Patients With Moderate Ischemic Stroke: An Exploratory Analysis of the THALES Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. Published online July 9, 2021. doi:10.1001/jamaneurol.2021.2440

This exploratory analysis of the THALES trial evaluates the efficacy and safety of ticagrelor plus aspirin in patients with moderate ischemic stroke (National Institutes of Health Stroke Scale score of 4 to 5).

July 6, 2021
Editorial

APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome—Implications for Clinical Trials and Treatments for All

Abstract Full Text
JAMA Neurol. Published online July 6, 2021. doi:10.1001/jamaneurol.2021.1649
Original Investigation

Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

Abstract Full Text
open access
JAMA Neurol. Published online July 6, 2021. doi:10.1001/jamaneurol.2021.1893

This cohort study examines Alzheimer disease symptoms and age at onset; changes in amyloid, tau, and neurodegeneration biomarkers; and topography of brain changes in adults with Down syndrome.

Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study

Abstract Full Text
JAMA Neurol. Published online July 6, 2021. doi:10.1001/jamaneurol.2021.2043

This cohort study assesses outcomes in major areas of life functions at 2 weeks and 3, 6, and 12 months after moderate to severe traumatic brain injury.

Comment & Response

Questions on Predicting Early Neurological Deterioration in Patients With Minor Stroke and Large-Vessel Occlusion

Abstract Full Text
JAMA Neurol. Published online July 6, 2021. doi:10.1001/jamaneurol.2021.2022

Questions on Predicting Early Neurological Deterioration in Patients With Minor Stroke and Large-Vessel Occlusion—Reply

Abstract Full Text
JAMA Neurol. Published online July 6, 2021. doi:10.1001/jamaneurol.2021.2025
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