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January 18, 2022
Viewpoint

The End Justifies the Means—A Call for Nuance in the Increasing Nationwide Adoption of Stereoelectroencephalography Over Subdural Electrode Monitoring in the Surgical Evaluation of Intractable Epilepsy

Abstract Full Text
JAMA Neurol. Published online January 18, 2022. doi:10.1001/jamaneurol.2021.4994

This Viewpoint discusses the considerations that should guide decision-making on the choice of stereoelectroencephalography vs subdural monitoring in each patient.

Original Investigation

Infarct on Brain Imaging, Subsequent Ischemic Stroke, and Clopidogrel-Aspirin Efficacy: A Post Hoc Analysis of a Randomized Clinical Trial

Abstract Full Text
has audio
JAMA Neurol. Published online January 18, 2022. doi:10.1001/jamaneurol.2021.4905

This post hoc analysis of a randomized clinical trial investigates whether the association of clopidogrel-aspirin treatment with stroke recurrence in patients with minor stroke or high-risk transient ischemic attack is modified by the presence of infarct on imaging attributed to the index event.

Images in Neurology

Magnetic Resonance Imaging Features of Tropical Candidal Meningoencephalitis

Abstract Full Text
JAMA Neurol. Published online January 18, 2022. doi:10.1001/jamaneurol.2021.4947

This case report describes the imaging features of a 66-year-old woman with earache and headache, mild left-sided weakness, and intermittent hallucinations and nonsensical speech who received a diagnosis of Candida tropicalis.

January 10, 2022
Editorial

Unintended Consequences of Approving Unproven Treatments—Hope, Hype, or Harm?

Abstract Full Text
JAMA Neurol. Published online January 10, 2022. doi:10.1001/jamaneurol.2021.4193
Original Investigation

Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis

Abstract Full Text
JAMA Neurol. Published online January 10, 2022. doi:10.1001/jamaneurol.2021.4893

This multicenter cohort study uses real-world clinical data to compare the long-term safety and effectiveness of intravenous edaravone plus riluzole therapy vs propensity score–matched controls receiving riluzole therapy alone among patients with amyotrophic lateral sclerosis.

JAMA Neurology Clinical Challenge

A Woman With Eosinophilic Brainstem Meningoencephalitis

Abstract Full Text
has active quiz
JAMA Neurol. Published online January 10, 2022. doi:10.1001/jamaneurol.2021.4861

A 25-year-old woman presented with headache, dysarthria, double vision, and dizziness for 1 week. She had traveled to northeastern Brazil 2 months before the onset of the neurological symptoms. What is your diagnosis?

Correction

Error in Figure

Abstract Full Text
free access
JAMA Neurol. Published online January 10, 2022. doi:10.1001/jamaneurol.2021.5146

Error in Title

Abstract Full Text
free access
JAMA Neurol. Published online January 10, 2022. doi:10.1001/jamaneurol.2021.5165
January 8, 2022
Original Investigation

Durability of Clinical and Quality-of-Life Outcomes of Closed-Loop Spinal Cord Stimulation for Chronic Back and Leg Pain: A Secondary Analysis of the Evoke Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online January 8, 2022. doi:10.1001/jamaneurol.2021.4998

This secondary analysis of a randomized clinical trial determines whether evoked compound action potentials–controlled, closed-loop spinal cord stimulator is associated with better outcomes compared with fixed-output, open-loop spinal cord stimulator at 24 months following implant.

January 4, 2022
Viewpoint

Bringing Alzheimer Disease Testing and Results Disclosure Into the 21st Century Cures Act

Abstract Full Text
JAMA Neurol. Published online January 4, 2022. doi:10.1001/jamaneurol.2021.4851

This Viewpoint discusses the pros and cons of the 21st Century Cures Act for Alzheimer disease–related testing and results disclosure.

Original Investigation

Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis

Abstract Full Text
open access
JAMA Neurol. Published online January 4, 2022. doi:10.1001/jamaneurol.2021.4781

This genome-wide association study identifies common variants associated with risk of essential tremor.

Comparison of Drug-Eluting Stent With Bare-Metal Stent in Patients With Symptomatic High-grade Intracranial Atherosclerotic Stenosis: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online January 4, 2022. doi:10.1001/jamaneurol.2021.4804

This randomized clinical trial evaluates the rate of in-stent restenosis and the risk of stroke recurrence after the placement of a drug-eluting stent vs standard bare-metal stent among patients with symptomatic high-grade intracranial atherosclerotic stenosis.

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