For decades, effective treatment for metastatic colorectal cancer (mCRC) was an almost impenetrable obstacle, with a single therapeutic option—fluorouracil. Outcomes were highly consistent across time and across trials, with a median overall survival (OS) of approximately 1 year. The last 20 years have seen highly clinically relevant improvements in not only OS but also progression-free survival (PFS) and response rates. In the most recently reported large first-line randomized trials, median OS has reached or exceeded 30 months.1
Sargent D. Improved Outcomes in Metastatic Colon Cancer: Giving Credit Where Credit Is Due. JAMA Oncol. 2015;1(6):795–796. doi:10.1001/jamaoncol.2015.1789
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