The results from randomized clinical trials indicate that adjuvant imatinib improves recurrence-free survival when administered after surgery to patients with operable gastrointestinal stromal tumor (GIST), and in one trial1 3 years of treatment with adjuvant imatinib improved also overall survival compared with 1 year of imatinib. At present, 3 years of adjuvant therapy with imatinib is considered the standard of care for patients who have undergone surgery for high-risk GIST, unless the tumor harbors a mutation that confers resistance to imatinib (eg, PDGFRA exon 18 mutation D842V) or is wild-type for both KIT and PDGFRA.
Joensuu H. Physician Estimations of the Risk of Gastrointestinal Stromal Tumor Recurrence—Not Accurate Enough? More Education May Be Needed. JAMA Oncol. 2015;1(6):805–806. doi:10.1001/jamaoncol.2015.2404
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