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Comment & Response
January 2016

Neoepitopes and CD3-Positive and CD8-Positive Cells in Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers

Author Affiliations
  • 1Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Postbus 9600, 2300 RC Leiden, the Netherlands
  • 2Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England
JAMA Oncol. 2016;2(1):141. doi:10.1001/jamaoncol.2015.3900

To the Editor We read with interest the Brief Report by Howitt and colleagues.1 Over the last few years, we have also studied the interesting subgroup of endometrial cancers (ECs) with mutation in the POLE proofreading exonuclease domain,2,3 and in particular their association with excellent prognosis,3,4 not mentioned by Howitt et al1 in their report.

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