Neoepitopes and CD3-Positive and CD8-Positive Cells in Polymerase e–Mutated and Microsatellite-Instable Endometrial Cancers—Reply

In Reply Our study¹ was initially submitted in January 2015 as an abstract for the 2015 American Society of Clinical Oncology Annual Meeting and was accepted in March 2015 as an oral presentation; it was subsequently submitted to JAMA Oncology in April 2015 before the study by van Gool et al² appeared online. The goal of our study was to address whether hypermutated (microsatellite-unstable [MSI]/POLE-mutant) endometrial cancers (ECs) were more immunogenic compared with microsatellite-stable (MSS) ECs, and not whether this association may account for the improved survival of POLE-mutated tumors; accordingly, no reference was made to studies reporting an association of POLE-mutated tumors with improved survival.