In Reply Dr Blumenfeld’s letter underscores our sentiment that superficial assessment of the studies on the efficacy of gonadotropin-releasing hormone agonist (GnRHa) in preserving fertility could lead to inaccurate conclusions.
Dr Blumenfeld cited his retrospective study that had numerous weaknesses, including the lack of uniformity in patient selection, which were highlighted in the commentary of Del Mastro and Lambertini.1 Therefore, the results cannot be considered as evidence for the efficacy of GnRHa cotreatment.
Isabelle Demeestere, Volkan Turan, Kutluk Oktay. Pregnancy Rate and Preservation of Cyclic Ovarian Function With Gonadotropin-Releasing Hormone Agonist Cotreatment During Chemotherapy—Reply. JAMA Oncol. 2016;2(4):546–547. doi:10.1001/jamaoncol.2015.5743