Different Platelet Count Thresholds to Guide Use of Prophylactic Platelet Transfusions for Patients With Hematological Disorders After Myelosuppressive Chemotherapy or Stem Cell Transplantation

Clinical Question  What is the optimal platelet count threshold for prophylactic platelet transfusions to minimize bleeding, platelet use, and adverse clinical outcomes in thrombocytopenic patients with hematological malignant neoplasms?

Bottom Line  Maintaining a higher platelet count threshold (≤20 × 10⁹/L or ≤30 × 10⁹/L) was not associated with less bleeding than the current standard (≤10 × 10⁹/L), but required more platelet transfusions (low-quality evidence).