To the Editor We read with interest the article by Nikiforov et al1 suggesting a nomenclature revision for encapsulated follicular variant of papillary thyroid cancer (EFVPTC). Given the indolence of these tumors, the authors proposed a different terminology: noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). By removing the word cancer, the authors hope to reduce unnecessary postthyroidectomy treatments (eg, radioactive iodine), to reduce the intensity of follow-up, and improve patients’ emotional well-being. Removing cancer terminology also entails a reclassification of these tumors from malignant to benign and, therefore, a foreseeable change in the accuracy of preoperative diagnostic tests, particularly the accuracy of molecular testing for indeterminate cytological subtypes to predict thyroid cancer.
Juan P. Brito, Naykky M. Singh Ospina, John C. Morris. Ramifications of New Terminology for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma. JAMA Oncol. 2016;2(8):1097. doi:10.1001/jamaoncol.2016.2208