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Comment & Response
January 2017

Human Papillomavirus Genotypes Conferring Poor Prognosis in Head and Neck Squamous Cell Carcinoma

Author Affiliations
  • 1Attikon Hospital, National Kapodistrian University of Athens, Athens, Greece
  • 2Biomedical Research Foundation Academy of Athens, Athens, Greece
  • 3Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut
JAMA Oncol. 2017;3(1):125. doi:10.1001/jamaoncol.2016.3409

To the Editor In their interesting research letter, Bratman and colleagues1 report that patients with head and neck squamous cell carcinoma associated with human papillomavirus (HPV) genotypes other than HPV-16 have inferior survival. They propose that this finding will affect patient selection in trials of treatment deintensification, which seek to minimize long-term toxic effects in patients with highly curable HPV-initiated oropharyngeal cancer. Data respecting the relative importance of p16 and HPV status in predicting outcome after chemoradiotherapy, as well as experience in cervical cancer, may be helpful in interpreting these results.

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