Clinical Question
Is up-front whole-brain radiotherapy required to treat multiple brain metastases from non–small-cell lung cancer when highly active targeted therapies are available?
Clinical Application
Patients with EGFR-mutant or ALK-positive non–small-cell lung cancer with brain metastases now have the potential to achieve a prolonged survival. Through use of highly active targeted therapies, whole-brain radiotherapy can be safely postponed, diminishing toxic effects that could impair quality of life.