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Comment & Response
August 2017

Vitamin D and Breast Cancer Survival: The Good and the Bad—In Reply

Author Affiliations
  • 1Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
  • 2Division of Research, Kaiser Permanente Northern California, Oakland, California
JAMA Oncol. 2017;3(8):1139-1140. doi:10.1001/jamaoncol.2017.1477

In Reply Braillon and Mormile raised some interesting points regarding our report of a positive association of serum vitamin D level with better breast cancer prognosis in the Pathways Study.1

Kaplan-Meier survival curves by tertiles of vitamin D level only began to separate after day 1500, similar to findings in an earlier study showing separation after 4 years.2 In addition to analyzing vitamin D levels in tertiles, we also tested it as a continuous variable, which showed similar trend (overall survival per 10 ng/mL increment: adjusted hazard ratio [HR], 0.81; 95% CI, 0.70-0.94; P = .005).