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October 2017

Human Papillomavirus Triage of Women With Atypical Squamous Cells of Undetermined Significance—Reduction of Overtreatment Needed

Author Affiliations
  • 1Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands
JAMA Oncol. 2017;3(10):1310-1311. doi:10.1001/jamaoncol.2017.1522

The aim of cervical cancer screening is to prevent mortality and incidence of cervical cancer. Population-based cervical cancer screening by quality-assured cytology has led to a significant decrease in mortality and incidence of cervical cancer by early detection and treatment of cervical cancer precursor lesions and low stages of cancer. Histologically, precursor lesions of cervical cancer are classified as cervical intraepithelial neoplasia (CIN), graded from CIN1 to CIN3 according to the severity of the lesion, defined as the width of the cervical epithelium (one-third to full thickness) consisting of morphologically abnormal cells. The reproducibility of grading CIN lesions by pathologists is at best 70%.1

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