To the Editor Pearlman et al reported that in screening patients with colorectal cancer (CRC) for inherited germline mutated genes predisposing to CRC, 13 of 72 (18%) “had mutations in genes not traditionally associated with CRC risk.”1(p464) They note that “all patients found to have pathogenic mutations received genetic counseling and current evidence-based guidelines for intensive cancer surveillance based on their mutation status.”1(p469) However, these guidelines are not based on any known relevance of incidentally discovered germline mutations.
Sorscher S. Mutation Frequencies in Patients With Early-Onset Colorectal Cancer. JAMA Oncol. 2017;3(11):1585. doi:10.1001/jamaoncol.2017.0009
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