A woman in her 80s with a history of recurrent oral cancer presented with a new, biopsy-confirmed, squamous cell carcinoma (SCC). Her oncologic history began 16 years ago with diagnosis and local resection of a lesion on the palate. Cancer recurrence at the left buccal mucosa was identified and excised 10 years later. She then was diagnosed with 3 recurrences of SCC in rapid succession. Each malignant neoplasm was locally resected and the patient was also treated with adjuvant radiotherapy for the last episode. She remained asymptomatic, and a routine surveillance clinical examination uncovered a sixth lesion at the margin of a palatal graft.