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Research Letter
May 2018

Association of High Body Mass Index and Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Virus Infection: A Korean Population-Based Cohort Study

Author Affiliations
  • 1Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea
  • 2Department of Family Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea
JAMA Oncol. 2018;4(5):737-739. doi:10.1001/jamaoncol.2018.0035

It is well established that obesity is associated with higher risk of hepatocellular carcinoma (HCC) in the general population.1 However, it is unclear whether body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]) is associated with the risk of HCC in patients with chronic hepatitis B virus (HBV) infection because previous studies have reported inconsistent results.2,3 In this study, using data from a large nationwide, population-based cohort database, we provide clinical evidence on the association between BMI and development of HCC among men and women with chronic HBV infection.