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Comment & Response
June 2018

Findings Linking Mismatch Repair Mutation With Age at Endometrial and Ovarian Cancer Onset in Lynch Syndrome

Author Affiliations
  • 1Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy
JAMA Oncol. 2018;4(6):889. doi:10.1001/jamaoncol.2018.0253

To the Editor We read with interest the article by Ryan and colleagues.1 We applaud the authors’ excellent investigation. The research shows the association between mutated genes (MLH1, MSH2, MSH6, or PMS2) and type of mutation (ie, truncated, splicing, large rearrangement) in one of the mismatch repair genes and the age at onset of Lynch syndrome–associated malignant neoplasms.