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Comment & Response
June 2018

Findings Linking Mismatch Repair Mutation With Age at Endometrial and Ovarian Cancer Onset in Lynch Syndrome

Author Affiliations
  • 1Department of Clinical Genetics, Leiden University Medical Centre, Leiden, the Netherlands
JAMA Oncol. 2018;4(6):889-890. doi:10.1001/jamaoncol.2018.0256

To the Editor We read with interest the article by Ryan et al1 suggesting that patients with truncating MLH1 mutations develop endometrial cancer (EC) at a later age compared with those with nontruncating mutations and that surveillance guidelines should be adapted to accommodate these findings. This is a relevant observation because interfamilial variance of the Lynch phenotype is a well-known problem and a tailor-made surveillance program would benefit patients. However, we believe that it is too early to draw such rigorous conclusions.

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