In Reply We are grateful for the opportunity to respond to Bogani and colleagues about our report of an association between type of mismatch repair mutation and age of cancer onset in Lynch syndrome.1 They correctly state that neither endometrial nor ovarian cancers are single disease entities; their histological subtypes reflect vast differences in their biological characteristics, clinical behavior, and prognosis. They point out that if Lynch syndrome–associated gynecological cancers are heterogeneous, they might pursue different clinical courses, and a unified approach to cancer surveillance may not be appropriate.
Crosbie EJ, Ryan NAJ, Evans DG. Findings Linking Mismatch Repair Mutation With Age at Endometrial and Ovarian Cancer Onset in Lynch Syndrome—Reply. JAMA Oncol. 2018;4(6):890–891. doi:10.1001/jamaoncol.2018.0280
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