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Comment & Response
June 2018

Findings Linking Mismatch Repair Mutation With Age at Endometrial and Ovarian Cancer Onset in Lynch Syndrome—Reply

Author Affiliations
  • 1Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary’s Hospital, Manchester, England
  • 2Department of Obstetrics and Gynaecology, Manchester University Foundation Trust, Manchester Academic Health Science Centre, Manchester, England
  • 3Division of Evolution and Genomic Medicine, Faculty of Biology, Medicine and Health, University of Manchester, St Mary’s Hospital, Manchester, England
  • 4Manchester Centre for Genomic Medicine, Manchester University Foundation Trust, Manchester Academic Health Science Centre, Manchester, England
JAMA Oncol. 2018;4(6):890-891. doi:10.1001/jamaoncol.2018.0280

In Reply We are grateful for the opportunity to respond to Bogani and colleagues about our report of an association between type of mismatch repair mutation and age of cancer onset in Lynch syndrome.1 They correctly state that neither endometrial nor ovarian cancers are single disease entities; their histological subtypes reflect vast differences in their biological characteristics, clinical behavior, and prognosis. They point out that if Lynch syndrome–associated gynecological cancers are heterogeneous, they might pursue different clinical courses, and a unified approach to cancer surveillance may not be appropriate.

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