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Comment & Response
April 12, 2018

Study Limitations in HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia

Author Affiliations
  • 1Haematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, England
JAMA Oncol. Published online April 12, 2018. doi:10.1001/jamaoncol.2018.0364

To the Editor In the recent article by Guo et al,1 the authors report outcomes of 4 age-defined cohorts receiving antileukemia drugs and a microtransplant. There are no controls not receiving a microtransplant, so it is impossible to know what impact the microtransplant, if any, had on the reported outcomes. Moreover, there is no attempt to account for obvious selection biases operating in the older subject cohorts. An explanation seems warranted.

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