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Comment & Response
July 2018

When You Hear Hoofbeats, Look for Horses, Not Zebras—Reply

Author Affiliations
  • 1Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
JAMA Oncol. 2018;4(7):1011-1012. doi:10.1001/jamaoncol.2018.0548

In Reply After the publication of our study identifying anaplastic lymphoma kinase (ALK) rearrangements in peritoneal mesothelioma,1 we read the Letter by Kataoka et al with skepticism. Because both peritoneal mesothelioma and primary peritoneal carcinoma are rare intra-abdominal tumors, Kataoka et al wonder whether our 3 cases of ALK-rearranged peritoneal mesothelioma may represent misdiagnoses and are instead primary peritoneal carcinomas with ALK rearrangement. We address their concern as follows.

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