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Comment & Response
July 2018

Testing Ashkenazi Jewish Women for Mutations Predisposing to Breast Cancer in Genes Other Than BRCA1 and BRCA2—Reply

Author Affiliations
  • 1Division of Medical Genetics, Department of Medicine, University of Washington, Seattle
  • 2Department of Genome Sciences, University of Washington, Seattle
JAMA Oncol. 2018;4(7):1012-1013. doi:10.1001/jamaoncol.2018.0616

In Reply Narod et al raise several concerns about our recent suggestion that women of Ashkenazi Jewish (AJ) ancestry consider comprehensive sequencing for inherited predisposition to breast and ovarian cancer. Our data1 led us to suggest that, given recent advances in sequencing technology and reductions in price, AJ women consider the same complete sequencing for all known breast cancer genes as women of other ancestries.

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