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Comment & Response
August 2018

Statistical Tests Used to Validate the American Joint Committee on Cancer Eighth Edition Prognostic Stage Compared With the Anatomic Stage in Breast Cancer

Author Affiliations
  • 1Merck Research Laboratories, Rahway, New Jersey
  • 2Henry Ford Health System, Detroit, Michigan
JAMA Oncol. 2018;4(8):1137. doi:10.1001/jamaoncol.2018.0884

To the Editor Weiss et al1 validated the American Joint Committee on Cancer Eighth Edition prognostic stage and compared it with the anatomic stage in breast cancer in 2 large cohorts. The authors used the Harrell C index to qualify the models’ predictive performance based on prognostic stage and anatomic stage, respectively. The authors further determined the significance between the Harrell C index of the prognostic stage and anatomic stage using the R package compareC. In the MD Anderson cohort, the Harrell C indices for the prognostic stage and the anatomic stage are 0.8357 and 0.7370 (P < .001). In the California Cancer Registry, the Harrell C indices for the prognostic stage and the anatomic stage are 0.8426 and 0.8097 (P < .001).

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