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Research Letter
January 2019

Association Between Polycystic Ovary Syndrome and Cancer Risk

Author Affiliations
  • 1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
  • 2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  • 3Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China
  • 4Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden
JAMA Oncol. 2019;5(1):106-107. doi:10.1001/jamaoncol.2018.5188

Inconsistent results have been reported for the association between polycystic ovary syndrome (PCOS) and risks of ovarian and breast cancers.1 Few studies had sufficient sample sizes, well-defined diagnostic criteria, or reasonable confounding adjustment.1,2 Even fewer studies have addressed the risks of other cancers. Thus, we conducted a large, population-based cohort study with a long follow-up period and rather sufficient confounding adjustment.