In Reply We thank Dr Sun et al and Dr Roussakow for their thoughtful comments on our recent article1 in JAMA Oncology.
Sun et al ask if overlapping median CIs contradict a significant difference in disease-free survival time. Slight overlap of CIs and reported significant difference is not a contradiction, as discussed by Austin and Hux.2 Furthermore, CIs for median overall survival (OS) do not exist because median OS cannot be estimated if the OS curves lay above the 50% survival margin.
Mansmann U, Lindner LH, Issels R. Regional Hyperthermia With Neoadjuvant Chemotherapy for Treatment of Soft Tissue Sarcoma—Reply. JAMA Oncol. Published online November 29, 2018. doi:10.1001/jamaoncol.2018.5293
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