Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene MSH6

To the Editor In “Association of Breast and Ovarian Cancers with Predisposition Genes Identified by Large-Scale Sequencing,” Lu et al¹ describe an association between invasive lobular breast cancer and mutations in the mismatch repair gene MSH6. The purported association is driven primarily by the increased frequency of 1 particular pathogenic variant, a single base deletion c.2945delC, compared with its frequency in 3988 in-laboratory controls referred for nononcological indications (OR, 4.23; 95% CI, 1.39-11.97). We believe this association is incorrect, caused by a sequencing artifact in the authors’ data sets.