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Comment & Response
January 2019

Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene MSH6—Reply

Author Affiliations
  • 1Ambry Genetics, Aliso Viejo, California
JAMA Oncol. 2019;5(1):121-122. doi:10.1001/jamaoncol.2018.6914

In Reply We appreciate the interest and comments by Narod, Evans et al, and Blanco et al concerning our recent sequencing study of more than 15 000 women with breast and/or ovarian cancer and unaffected controls.1 The authors raise several points for consideration: interpretation of reported odds ratios (ORs), assessment of our findings for syndromic genes such as NF1 and PTEN, and examination of a specific variant that contributes to our observed association between MSH6 and breast cancer.

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