Reduced Hepatocellular Carcinoma Risk vs Bleeding Risk Associated With Aspirin

To the Editor We read with interest the study by Simon and colleagues¹ that analyzed data from the Nurses’ Health Study and the Health Professionals Follow-up Study and found that long-term aspirin use was associated with reduced risk for hepatocellular carcinoma (HCC). Because HCC carries a high mortality rate, prevention is key. We applaud the authors for investigating aspirin as a possible prevention method. However, we have several concerns.