To the Editor We read with interest the study by Simon and colleagues1 that analyzed data from the Nurses’ Health Study and the Health Professionals Follow-up Study and found that long-term aspirin use was associated with reduced risk for hepatocellular carcinoma (HCC). Because HCC carries a high mortality rate, prevention is key. We applaud the authors for investigating aspirin as a possible prevention method. However, we have several concerns.
Chien N, Yeo YH, Nguyen MH. Reduced Hepatocellular Carcinoma Risk vs Bleeding Risk Associated With Aspirin. JAMA Oncol. Published online May 02, 20195(6):911. doi:10.1001/jamaoncol.2019.0614
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