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Comment & Response
May 2, 2019

Reduced Hepatocellular Carcinoma Risk vs Bleeding Risk Associated With Aspirin

Author Affiliations
  • 1Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California
JAMA Oncol. 2019;5(6):911. doi:10.1001/jamaoncol.2019.0614

To the Editor We read with interest the study by Simon and colleagues1 that analyzed data from the Nurses’ Health Study and the Health Professionals Follow-up Study and found that long-term aspirin use was associated with reduced risk for hepatocellular carcinoma (HCC). Because HCC carries a high mortality rate, prevention is key. We applaud the authors for investigating aspirin as a possible prevention method. However, we have several concerns.

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