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Comment & Response
July 3, 2019

Analysis of Pathologic Complete Response 10 Weeks After Radiotherapy—A Radiobiological Sin

Author Affiliations
  • 1Department of Radiation Oncology, Weill Cornell Medicine, New York, New York
JAMA Oncol. Published online July 3, 2019. doi:10.1001/jamaoncol.2019.1882

To the Editor In the Measuring the Integration of Stereotactic Ablative Radiotherapy Plus Surgery for Early Stage Non–Small Cell Lung Cancer (MISSILE-NSCLC) trial, Palma and colleagues1 reported on a well-executed phase 2 trial of stereotactic ablative radiotherapy (SABR) followed by definitive resection in early-stage NSCLC. Surprisingly, this study showed that the pathological complete response (pCR) rate was only 60% at 10 weeks after SABR. This is substantially lower than the assumed pCR rate and challenges us to revisit some commonly held assumptions about SABR.

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