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Comment & Response
July 3, 2019

Analysis of Pathologic Complete Response 10 Weeks After Radiotherapy—A Radiobiological Sin

Author Affiliations
  • 1Graduate Education Center, Shandong Academy of Medical Sciences, Jinan, Shandong, China
  • 2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China
JAMA Oncol. Published online July 3, 2019. doi:10.1001/jamaoncol.2019.1890

To the Editor We read with great interest the article by Palma and colleagues1 published in JAMA Oncology. Unexpectedly, stereotactic ablative radiotherapy (SABR) resulted in a pathologic complete response (pCR) rate of only 60%; this rate is lower than the local control (LC) rate of SABR alone, which is generally higher than 90%.2 The authors explained that the limitation of hematoxylin-eosin staining technology and short waiting time between SABR and surgery may have contributed to underestimation of the pCR rate.1 However, more issues still need to be discussed.