To the Editor Smith et al1 reported the results of 113 patients with rectal cancer who underwent a watch-and-wait (WW) strategy after clinical complete response (cCR) to neoadjuvant therapy and 136 patients with pathologic complete response (pCR) identified at total mesorectal excision (TME). Although this study adds to a body of retrospective literature, key knowledge gaps limiting widespread use of WW remain.
Dossa F, Moore SE, Baxter NN. Looking Forward, Not Backward, on Watch and Wait for Rectal Cancer. JAMA Oncol. 2019;5(8):1230–1231. doi:10.1001/jamaoncol.2019.1867
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